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首页> 外文期刊>Journal of biochemical and molecular toxicology >Constitutive expression and induction of CYP1B1 mRNA in the mouse.
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Constitutive expression and induction of CYP1B1 mRNA in the mouse.

机译：CYP1B1 mRNA在小鼠中的组成型表达和诱导。

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摘要

Previous studies appeared to indicate that CYP1B1 was not constitutively expressed in mouse liver. In our laboratory, we demonstrated using aromatic hydrocarbon-responsive receptor knock-out (AHR-(-)/-) mice that both piperonyl butoxide (PBO) and acenaphtyhlene (ACN) are AHR-independent inducers of murine CYP1A2 and CYP1B1 mRNA. In the current study, we demonstrate both constitutive levels and induction of CYP1B1 in mouse liver. The induction of CYP1B1 mRNA by PBO or ACN was higher in DBA/2 (Ahrd) than in C57BL/6 (Ahrb-1) mice, while 3-methylcholanthrene induced CYP1B1 more in C57BL/6 than in DBA/2 mice. These results suggest that CYP1B1 may also be induced by more than one mechanism. In addition, constitutive expression of CYP1B1 was detected in liver, kidney, and lung of untreated C57BL/6 mice. There was no gender difference in CYP1B1 expression; however, in C57BL/6 mice, the kidney contained less CYP1B1 than either liver or lung.
机译：先前的研究似乎表明CYP1B1在小鼠肝脏中不组成性表达。在我们的实验室中，我们证明了使用芳烃反应受体敲除（AHR-（-）/-）小鼠，胡椒基丁醚（PBO）和烯（ACN）都是鼠CYP1A2和CYP1B1 mRNA的非AHR诱导剂。在当前的研究中，我们证明了CYP1B1在小鼠肝脏中的组成水平和诱导作用。 PBO或ACN对CYP1B1 mRNA的诱导在DBA / 2（Ahrd）中比在C57BL / 6（Ahrb-1）小鼠中高，而3-甲基胆碱在C57BL / 6中诱导的CYP1B1比在DBA / 2小鼠中高。这些结果提示CYP1B1也可能由多种机制诱导。另外，在未治疗的C57BL / 6小鼠的肝，肾和肺中检测到CYP1B1的组成型表达。 CYP1B1表达无性别差异。然而，在C57BL / 6小鼠中，肾脏所含的CYP1B1少于肝脏或肺。

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