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首页> 外文期刊>Journal of biochemical and molecular toxicology >Modulatory effects of lipoic acid and selenium against cadmium-induced biochemical alterations in testicular steroidogenesis.
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Modulatory effects of lipoic acid and selenium against cadmium-induced biochemical alterations in testicular steroidogenesis.

机译：硫辛酸和硒对睾丸类固醇生成中镉诱导的生化变化的调节作用。

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摘要

Exposure to toxic metals including cadmium has become an increasingly recognized source of illness worldwide. Cadmium (Cd(2+) ) is one of the environmental pollutants affecting various tissues and organs including testis. The protective effect of lipoic acid and selenium on Cd(2+) -induced testicular damage was investigated. Accordingly, male Wistar rats were allocated into four groups (n = 8; each). Gp I: (control), whereas the other 3 groups received CdCl(2) (2 mg/kg, i.p. for 28 days) alone or in combination with either (i) lipoic acid (35 mg/kg, p.o) or (ii) selenium (0.35 mg/kg, p.o) throughout the experiment. Serum testosterone, luteinizing hormone and follicle-stimulating hormone levels significantly decreased in the Cd(2+) -exposed rats. The activities of testicular key androgenic enzymes, 3beta-hydroxysteroid dehydrogenase and 17 beta-HSD significantly decreased in Cd(2) exposed rats compared to the control counterparts. In addition, the activities of testicular marker enzymes were significantly altered in cadmium-treated animals. Significant reductions in body and testicular weight as well as antioxidant status were also observed in Cd(2+) -exposed rats. Moreover, some testicular metal levels were altered. Lipoic acid and selenium significantly increased serum testosterone level and restored testicular activity of 3beta-HSD and 17 beta-HSD and were effective in modulation of most of the measured biochemical parameters. The biochemical parameters were further confirmed with histopathological findings. In conclusion, the present study demonstrated the beneficial influences of lipoic acid and selenium in reducing harmful effects of Cd(2+) in rats' testes.
机译：暴露于包括镉在内的有毒金属已成为全球公认的疾病来源。镉（Cd（2+））是影响包括睾丸在内的各种组织和器官的环境污染物之一。研究了硫辛酸和硒对Cd（2+）诱导的睾丸损伤的保护作用。因此，将雄性Wistar大鼠分成四组（n ＝ 8;每组）。 Gp I ：（对照组），而其他3组单独或与（i）硫辛酸（35 mg / kg，口服）或（ii）联合使用CdCl（2）（2 mg / kg，腹腔注射28天）整个实验过程中的硒（0.35 mg / kg，po）。暴露于Cd（2+）的大鼠的血清睾丸激素，促黄体生成素和促卵泡激素水平显着降低。与对照组相比，Cd（2）暴露的大鼠睾丸关键雄激素酶，3β-羟类固醇脱氢酶和17β-HSD的活性显着降低。另外，在镉处理的动物中睾丸标志物酶的活性发生了显着变化。在Cd（2+）暴露的大鼠中也观察到体重和睾丸重量以及抗氧化剂状态的显着降低。此外，一些睾丸金属水平发生了改变。硫辛酸和硒显着提高了血清睾丸激素水平，并恢复了3beta-HSD和17 beta-HSD的睾丸活性，并且可以有效地调节大多数测得的生化参数。通过组织病理学发现进一步证实了生化参数。总之，本研究证明了硫辛酸和硒对降低大鼠睾丸中Cd（2+）的有害作用的有益影响。

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