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首页> 外文期刊>Journal of biochemical and molecular toxicology >Antigenotoxic properties of two newly synthesized β-aminoketones against N-methyl-N'-nitro-N-nitrosoguanidine and 9-aminoacridine-induced mutagenesis
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Antigenotoxic properties of two newly synthesized β-aminoketones against N-methyl-N'-nitro-N-nitrosoguanidine and 9-aminoacridine-induced mutagenesis

机译：两种新合成的β-氨基酮类对N-甲基-N'-硝基-N-亚硝基胍和9-氨基ac啶诱导的诱变的抗药性

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摘要

The aim of this study was to determine the antigenotoxic potential of two newly synthesized β-aminoketones against N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and 9-aminoacridine (9-AA)-induced mutagenesis. The mutant bacterial tester strains were MNNG-sensitive Escherichia coli WP2 uvrA and 9-AA-sensitive Salmonella typhimurium TA1537. Both test compounds showed significant antimutagenic activity at various tested concentrations. The inhibition rates ranged from 29.5% (compound 1: 2 mM/plate) to 47.5% (compound 2: 1.5 mM/plate) for MNNG and from 25.0% (compound 2: 1 mM/plate) to 52.1% (compound 2: 2.5 mM/plate) for 9-AA genotoxicity. Moreover, the mutagenicity of the test compounds was investigated by using the same strains. Neither test compound has mutagenic properties on the bacterial strains at the tested concentrations. Thus, the findings of the present study give valuable information about chemical prevention from MNNG and 9-AA genotoxicity by using synthetic β-aminoketones.
机译：这项研究的目的是确定两种新合成的β-氨基酮对N-甲基-N'-硝基-N-亚硝基胍（MNNG）和9-氨基ac啶（9-AA）诱导的诱变作用。突变的细菌测试菌株为MNNG敏感的大肠杆菌WP2 uvrA和9-AA敏感的鼠伤寒沙门氏菌TA1537。两种测试化合物在各种测试浓度下均显示出显着的抗诱变活性。 MNNG的抑制率范围为29.5％（化合物1：2 mM /板）至47.5％（化合物2：1.5 mM /板）和25.0％（化合物2：1 mM /板）至52.1％（化合物2： 2.5 mM /板）的9-AA遗传毒性。此外，通过使用相同菌株研究了测试化合物的诱变性。在测试浓度下，两种测试化合物均未对细菌菌株具有诱变特性。因此，本研究的发现为使用合成的β-氨基酮类化合物预防MNNG和9-AA遗传毒性提供了有价值的信息。

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