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首页> 外文期刊>Journal of biochemical and molecular toxicology >Induction of neuronal damage in guinea pig brain by intratracheal infusion of 2-chloroethyl ethyl sulfide, a mustard gas analog.
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Induction of neuronal damage in guinea pig brain by intratracheal infusion of 2-chloroethyl ethyl sulfide, a mustard gas analog.

机译：气管内注入芥子气类似物2-氯乙基乙基硫醚诱导豚鼠脑神经元损伤。

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Intratracheal infusion of 2-chloroethyl ethyl sulfide (CEES), a mustard gas analog and a chemical warfare agent is known to cause massive damage to lung. The purpose of this study was to determine whether intratracheal CEES infusion causes neuronal damage. Histological, immunohistochemical, and Western blot studies indicated that CEES treatment caused dose-dependent increases in blood cell aggregation, microglial cell number, microglial activation, and brain inflammation. In addition, an increased expression of α-synuclein and a decreased expression of the dopamine transporter were observed. The results indicate that intratracheal CEES infusion is associated with changes in brain morphology mediated by an increase in α-synuclein expression, leading to neurotoxicity in a guinea pig model. These changes may be mediated by oxidative stress. Furthermore, the present study indicates for the first time that intratracheal infusion of a single dose of CEES can cause neuroinflammation, which may lead to neurological disorders in later part of life.
机译：气管内注入2-氯乙基乙基硫（CEES），芥子气类似物和化学战剂对肺部造成巨大损害。这项研究的目的是确定气管内CEES灌注是否引起神经元损伤。组织学，免疫组织化学和蛋白质印迹研究表明，CEES治疗引起血细胞聚集，小胶质细胞数量，小胶质细胞活化和脑部炎症的剂量依赖性增加。另外，观察到α-突触核蛋白的表达增加和多巴胺转运蛋白的表达减少。结果表明，气管内CEES输注与脑形态变化有关，介导的α-突触核蛋白表达增加介导了豚鼠模型的神经毒性。这些变化可能是由氧化应激介导的。此外，本研究首次表明，气管内单剂量CEES输注可引起神经炎症，这可能会导致生命后期出现神经系统疾病。

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