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首页> 外文期刊>Journal of biochemical and molecular toxicology >Effects of Buprenorphine on Balance of Oxidant/Antioxidant System in the Different Ages of Male Rat Liver
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Effects of Buprenorphine on Balance of Oxidant/Antioxidant System in the Different Ages of Male Rat Liver

机译：丁丙诺啡对不同年龄雄性大鼠肝脏氧化/抗氧化系统平衡的影响

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摘要

Our knowledge about a link between buprenorphine and hepatotoxicity is controversial. This study evaluated the effects of buprenorphine on the liver of young, adult, and aged rats. For this reason, young, adult, and aged rats received intraperitoneally 0.25, 0.5, and 1 mg/kg buprenorphine for 30 days. The present results revealed that the normal aging was associated with a significant decrease in the activities of antioxidant enzymes, and an increase in the liver lipid peroxidation, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) activities in the aged rats. This study also demonstrated that buprenorphine led to a significant increase in the serum activities of ALT, AST, and LDH as well as liver lipid peroxidation content with a decrease in the antioxidant enzymes in the liver of buprenorphine-treated aged rat versus the aged matched control animals. In conclusion, the present results demonstrate that buprenorphine deteriorated oxidative damage in the aged livers. (C) 2015 Wiley Periodicals, Inc.
机译：我们对丁丙诺啡与肝毒性之间的联系的认识存在争议。这项研究评估了丁丙诺啡对年轻，成年和老年大鼠肝脏的影响。因此，年轻，成年和老年大鼠的腹膜内接受0.25、0.5和1 mg / kg丁丙诺啡30天。目前的结果表明，正常衰老与抗氧化酶活性的显着降低以及肝脏脂质过氧化，血清天冬氨酸氨基转移酶（AST），丙氨酸氨基转移酶（ALT）和乳酸脱氢酶（LDH）活性的增加有关。在老年大鼠中。这项研究还表明，丁丙诺啡治疗的老年大鼠与老年配对对照组相比，丁丙诺啡导致血清ALT，AST和LDH活性显着增加以及肝脂质过氧化含量降低，肝脏中的抗氧化酶降低动物。总之，目前的结果表明丁丙诺啡使老年肝脏的氧化损伤恶化。 （C）2015威利期刊公司

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