...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biochemical and molecular toxicology >Thymol and Carvacrol Prevent Cisplatin-Induced Nephrotoxicity by Abrogation of Oxidative Stress, Inflammation, and Apoptosis in Rats
【24h】

Thymol and Carvacrol Prevent Cisplatin-Induced Nephrotoxicity by Abrogation of Oxidative Stress, Inflammation, and Apoptosis in Rats

机译：百里香酚和香芹酚通过消除大鼠的氧化应激，炎症和细胞凋亡来预防顺铂诱导的肾毒性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim of the present study is to assess the possible protective effects of thymol and carvacrol against cisplatin (CP)-induced nephrotoxicity. A single dose of CP {6 mg/kg, intraperitoneally (i.p.)} injected to male rats revealed significant increases in serum urea, creatinine, and tumor necrosis factor alpha levels. It also increased kidney contents of malondialdehyde and caspase-3 activity with significant reduction in serum albumin, kidney content of reduced glutathione as well as catalase, and superoxide dismutase activity as compared to that of the control group. In contrast, administration of thymol {20 mg/kg, orally (p.o.)} and/or carvacrol (15 mg/kg, p.o.) for 14 days before CP injection and for 7 days after CP administration restored the kidney function and examined oxidative stress parameters. In conclusion, thymol was more effective nephroprotective than carvacrol. Moreover, a combination of thymol and carvacrol had a synergistic nephroprotective effect that might be attributed to antioxidant, anti-inflammatory, and antiapoptotic activities.
机译：本研究的目的是评估百里酚和香芹酚对顺铂（CP）诱导的肾毒性的可能的保护作用。向雄性大鼠腹膜内（i.p.）注射单剂量的CP {6 mg / kg}显示血清尿素，肌酐和肿瘤坏死因子α水平显着增加。与对照组相比，它还增加了丙二醛的肾脏含量和caspase-3活性，同时血清白蛋白显着降低，谷胱甘肽还原酶，过氧化氢酶的肾脏含量和超氧化物歧化酶活性显着降低。相反，在CP注射前14天和CP注射后7天给予百里酚{20 mg / kg，口服（po）}和/或香芹酚（15 mg / kg，po），可恢复肾脏功能并检查氧化应激参数。总之，百里酚比香芹酚更有效地保护肾脏。此外，百里酚和香芹酚的组合具有协同的肾保护作用，这可能归因于抗氧化剂，抗炎和抗凋亡活性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号