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首页> 外文期刊>Journal of biochemical and molecular toxicology >The Effects of Boron on Arsenic-Induced Lipid Peroxidation and Antioxidant Status in Male and Female Rats
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The Effects of Boron on Arsenic-Induced Lipid Peroxidation and Antioxidant Status in Male and Female Rats

机译：硼对雄性和雌性大鼠砷诱导的脂质过氧化和抗氧化状态的影响

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摘要

The aim of the present study was to investigate the possible protective effects of boron, an antioxidant agent, against arsenic-induced oxidative stress in male and female rats. In total, 42 Wistar albino male and female rats were divided into three equal groups: The animals in the control group were given normal drinking water, the second group was given drinking water with 100 mg/L arsenic, and the third group was orally administered drinking water with 100 mg/kg boron together with arsenic. At the end of the 28-day experiment, arsenic increased lipid peroxidation and damage in the tissues of rats. However, boron treatment reversed this arsenic-induced lipid peroxidation and activities of antioxidant enzymes in rats. Moreover, boron exhibited a protective action against arsenic-induced histopathological changes in the tissues of rats. In conclusion, boron was found to be effective in protecting rats against arsenic-induced lipid peroxidation by enhancing antioxidant defense mechanisms. (C) 2015 Wiley Periodicals, Inc.
机译：本研究的目的是研究抗氧化剂硼对雄性和雌性大鼠砷诱导的氧化应激的可能的保护作用。总共将42只Wistar白化病雄性和雌性大鼠分为三等分：对照组中的动物被给予正常饮用水，第二组被给予100 mg / L砷的饮用水，第三组被口服给药含100 mg / kg硼和砷的饮用水。在28天的实验结束时，砷增加了大鼠组织中脂质的过氧化作用和损伤。然而，硼处理逆转了砷诱导的大鼠脂质过氧化和抗氧化酶的活性。此外，硼对大鼠组织中砷诱导的组织病理学变化具有保护作用。总之，发现硼通过增强抗氧化防御机制，可有效保护大鼠免受砷诱导的脂质过氧化作用。 （C）2015威利期刊公司

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