• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biochemical and molecular toxicology >Low-carbohydrate diet and oxidative stress in diabetic and nondiabetic rats.
【24h】

Low-carbohydrate diet and oxidative stress in diabetic and nondiabetic rats.

机译：糖尿病和非糖尿病大鼠的低碳水化合物饮食和氧化应激。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Hyperglycemia of diabetes has been implicated in increased tissue oxidative stress, with consequent development of secondary complications. Thus, stabilizing glucose levels near normal levels is of utmost importance. Because diet influences glycemic control, this study investigated whether a low-carbohydrate (5.5%) diet confers beneficial effects on the oxidative status of the heart, kidney, and liver in diabetes. Male and female normal and diabetic rats were fed standard chow (63% carbohydrates) or low-carbohydrate diet for 30 days. Elevated glucose, HbA(1c), and alanine and aspartate aminotransferases in diabetic animals were reduced or normalized by the low-carbohydrate diet. While diabetes increased cardiac activities of glutathione peroxidase and catalase, low-carbohydrate diet normalized cardiac glutathione peroxidase activity in diabetic animals, and reduced catalase activity in females. Diabetic rats fed low-carbohydrate diet had altered activities of renal glutathione reductase and superoxide dismutase, but increased renal glutathione peroxidase activity in diabetic animals was not corrected by the test diet. In the liver, diabetes was associated with a decrease in catalase activity and glutathione levels and an increase in glutathione peroxidase and gamma-glutamyltranspeptidase activities. Decreased hepatic glutathione peroxidase activity and lipid peroxidation were noted in diet-treated diabetic rats. Overall, the low-carbohydrate diet helped stabilize hyperglycemia and did not produce overtly negative effects in tissues of normal or diabetic rats.
机译：糖尿病的高血糖与组织氧化应激的增加有关，继发继发并发症。因此，将葡萄糖水平稳定在接近正常水平至关重要。由于饮食会影响血糖控制，因此本研究调查了低碳水化合物饮食（5.5％）是否对糖尿病患者的心脏，肾脏和肝脏的氧化状态具有有益作用。给雄性和雌性正常和糖尿病大鼠喂食标准食物（63％的碳水化合物）或低碳水化合物饮食30天。低碳水化合物饮食可降低糖尿病动物的血糖，HbA（1c），丙氨酸和天冬氨酸转氨酶升高或使其正常化。糖尿病会增加谷胱甘肽过氧化物酶和过氧化氢酶的心脏活性，而低碳水化合物饮食可以使糖尿病动物的心脏谷胱甘肽过氧化物酶的活性正常化，而雌性则降低了过氧化氢酶的活性。用低碳水化合物饮食喂养的糖尿病大鼠肾脏谷胱甘肽还原酶和超氧化物歧化酶的活性发生了改变，但是糖尿病动物肾脏谷胱甘肽过氧化物酶活性的升高并未通过试验饮食纠正。在肝脏中，糖尿病与过氧化氢酶活性和谷胱甘肽水平降低以及谷胱甘肽过氧化物酶和γ-谷氨酰转肽酶活性升高有关。在饮食治疗的糖尿病大鼠中，肝谷胱甘肽过氧化物酶活性和脂质过氧化作用降低。总体而言，低碳水化合物饮食有助于稳定高血糖症，并且不会对正常或糖尿病大鼠的组织产生明显的负面影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号