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首页> 外文期刊>Journal of biochemical and molecular toxicology >Toxicological Implications and Inflammatory Response in Human Lymphocytes Challenged with Oxytetracycline
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Toxicological Implications and Inflammatory Response in Human Lymphocytes Challenged with Oxytetracycline

机译：土霉素挑战的人类淋巴细胞的毒理学意义和炎症反应。

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摘要

Antibiotics are widely used in zoo technical and veterinary practices as feed supplementation to ensure wellness of farmed animals and livestock. Several evidences have been suggesting both the toxic role for tetracyclines, particularly for oxytetracycline (OTC). This potential toxicity appears of great relevance for human nutrition and for domestic animals. This study aimed to extend the evaluation of such toxicity. The biologic impact of the drug was assessed by evaluating the proinflammatory effect of OTC and their bone residues on cytokine secretion by in vitro human peripheral blood lymphocytes. Our results showed that both OTC and OTC-bone residues significantly induced the T lymphocyte and non-T cell secretion of interferon (IFN)-, as cytokine involved in inflammatory responses in humans as well as in animals. These results may suggest a possible implication for new potential human and animal health risks depending on the entry of tetracyclines in the food-processing chain.
机译：抗生素广泛用于动物园的技术和兽医实践中，作为饲料补充品，以确保养殖动物和牲畜的健康。已有证据表明四环素，特别是土霉素（OTC）具有毒性作用。这种潜在的毒性看来与人类营养和家畜息息相关。这项研究旨在扩展这种毒性的评估。通过评估OTC及其骨残留物对体外人外周血淋巴细胞对细胞因子分泌的促炎作用，评估了该药的生物学影响。我们的研究结果表明，OTC和OTC-骨残基均能显着诱导T淋巴细胞和干扰素（IFN）-的非T细胞分泌，因为细胞因子参与了人类和动物的炎症反应。这些结果可能暗示对新的潜在人类和动物健康风险的暗示，这取决于四环素在食品加工链中的进入。

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