The Effects of the Organic Flame-Retardant 1,2-Dibromo-4-(1,2-dibromoethyl) Cyclohexane (TBECH) on Androgen Signaling in Human Prostate Cancer Cell Lines

Wong Lilian I. L.; Reers Alexandra R.; Currier Heidi A.; Williams Tony D.; Cox Michael E.; Elliott John E.; Beischlag Timothy V.

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The Effects of the Organic Flame-Retardant 1,2-Dibromo-4-(1,2-dibromoethyl) Cyclohexane (TBECH) on Androgen Signaling in Human Prostate Cancer Cell Lines

机译：有机阻燃剂1,2-二溴-4-（1,2-二溴乙基）环己烷（TBECH）对人前列腺癌细胞系雄激素信号的影响

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The effects of the organic flame retardant 1,2-Dibromo-4-(1,2-dibromoethyl) cyclohexane (TBECH) on androgen receptor target gene expression were examined in the human LNCaP prostate cancer cell line. While gamma-/delta-TBECH alone led to a significant increase in prostate-specific antigen (PSA) mRNA accumulation, both the alpha-/-TBECH and gamma-/delta-TBECH mixtures repressed androgen-inducible PSA mRNA and protein accumulation in human LNCaP cells. Thus, we hypothesize that isomeric mixtures of TBECH may act as partial agonists of the androgen receptor. (C) 2015 Wiley Periodicals, Inc.

机译：在人类LNCaP前列腺癌细胞系中检查了有机阻燃剂1,2-二溴-4-（1,2-二溴乙基）环己烷（TBECH）对雄激素受体靶基因表达的影响。虽然单独使用γ-/δ-TBECH会导致前列腺特异性抗原（PSA）mRNA的积累显着增加，但是α-/-TBECH和γ-/δ-TBECH的混合物均会抑制人类中雄激素诱导的PSA mRNA和蛋白的积累LNCaP细胞。因此，我们假设TBECH的异构体混合物可能充当雄激素受体的部分激动剂。（C）2015年Wiley Periodicals，Inc.

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《Journal of biochemical and molecular toxicology》 |2016年第5期|共4页
作者
Wong Lilian I. L.; Reers Alexandra R.; Currier Heidi A.; Williams Tony D.; Cox Michael E.; Elliott John E.; Beischlag Timothy V.;
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正文语种 eng
中图分类生物化学;
关键词
Organic Flame Retardant; Endocrine Disruptor; Androgen Receptor; LNCaP;

机译：有机阻燃剂内分泌干扰素雄激素受体LNCaP;

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1. The Effects of the Organic Flame-Retardant 1,2-Dibromo-4-(1,2-dibromoethyl) Cyclohexane (TBECH) on Androgen Signaling in Human Prostate Cancer Cell Lines [J] . Wong Lilian I. L., Reers Alexandra R., Currier Heidi A., Journal of biochemical and molecular toxicology . 2016,第5期

机译：有机阻燃剂1,2-二溴-4-（1,2-二溴乙基）环己烷（TBECH）对人前列腺癌细胞系雄激素信号的影响
2. TBECH, 1,2-dibromo-4-(1,2 dibromoethyl) cyclohexane, alters androgen receptor regulation in response to mutations associated with prostate cancer [J] . Kharlyngdoh Joubert Banjop, Asnake Solomon, Pradhan Ajay, Toxicology and Applied Pharmacology . 2016,第Null期

机译：TBECH，1,2-二溴-4-（1,2，二溴乙基）环己烷，响应与前列腺癌相关的突变而改变雄激素受体的调节
3. TBECH, 1,2-dibromo-4-(1,2 dibromoethyl) cyclohexane, alters androgen receptor regulation in response to mutations associated with prostate cancer [J] . Kharlyngdoh Joubert Banjop, Asnake Solomon, Pradhan Ajay, Toxicology and Applied Pharmacology . 2016,第Null期

机译：Tbech，1,2-二溴-4-（1,2二溴乙基）环己烷，改变雄激素受体调节，响应与前列腺癌相关的突变
4. Investigation of androgen effects on prostate cancer cell lines by near-infrared Raman microspectroscopy [C] . Abdelilah Beljebbar, Erasmus Univ. Rotterdam, Univ. Hospital Rotterdam, Biomedical Spectroscopy: Vibrational Spectroscopy and Other Novel Techniques . 2000

机译：近红外拉曼光谱研究雄激素对前列腺癌细胞系的作用
5. Dietary exposure of 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane to juvenile brown trout (Salmo trutta): Bioaccumulation parameters and effects on circulating plasma sex hormones [D] . Gemmill, Bonnie 2010

机译：少年鳟鱼（Salmo trutta）对1,2-二溴-4-（1,2-二溴乙基）环己烷的饮食暴露：生物蓄积参数及其对血浆血浆性激素的影响
6. Diastereomers of the Brominated Flame Retardant 1,2-Dibromo-4-(1,2 dibromoethyl)cyclohexane Induce Androgen Receptor Activation in the HepG2 Hepatocellular Carcinoma Cell Line and the LNCaP Prostate Cancer Cell Line [O] . Hazem Khalaf, Anders Larsson, Håkan Berg, 2017

机译：溴化阻燃剂1,2-二溴4-（1,2-二溴乙基）环己烷的非对映异构体在HepG2肝细胞癌细胞系和LNCaP前列腺癌细胞系中诱导雄激素受体活化
7. Research Diastereomers of the Brominated Flame Retardant 1,2-Dibromo-4-(1,2 dibromoethyl)cyclohexane Induce Androgen Receptor Activation in the HepG2 Hepatocellular Carcinoma Cell Line and the LNCaP Prostate Cancer Cell Line [O] . Hazem Khalaf, Anders Larsson, Håkan Berg, 2013

机译：溴化阻燃剂1,2-二溴-4-（1,2-二溴乙基）环己烷的非对映异构体在HepG2肝癌细胞系和LNCaP前列腺癌细胞系中诱导雄激素受体活化
8. Molecular Determinants of Prostate Cancer Progression Across Race- Ethnicity. Project A - The Human 5RD5A2 Gene and Prostate Cancer Progression. Project B - Androgen Receptor (AR) Signaling in Prostate Cancer Progression. Project C - Cellular and Molecular Markers of Prostate Cancer Progression Core - Epidemiology Core [R] . Ross, R. R. , Reichardt, J. , Coetzee, G. A. , 2002

机译：跨越种族的前列腺癌进展的分子决定因素。项目a - 人类5RD5a2基因和前列腺癌进展。项目B - 雄激素受体（aR）在前列腺癌进展中的信号传导。项目C - 前列腺癌进展核心的细胞和分子标记 - 流行病学核心

The Effects of the Organic Flame-Retardant 1,2-Dibromo-4-(1,2-dibromoethyl) Cyclohexane (TBECH) on Androgen Signaling in Human Prostate Cancer Cell Lines

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