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首页> 外文期刊>Journal of biochemical and molecular toxicology >Effect of 3,4-di(OH)-cinnamate synthetic derivative on plasma and hepatic cholesterol level and antioxidant enzyme activities in high cholesterol-fed rats.
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Effect of 3,4-di(OH)-cinnamate synthetic derivative on plasma and hepatic cholesterol level and antioxidant enzyme activities in high cholesterol-fed rats.

机译：3,4-二（OH）-肉桂酸酯合成衍生物对高胆固醇饮食大鼠血浆和肝胆固醇水平及抗氧化酶活性的影响。

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摘要

The effect of 3,4-di(OH)-phenylpropionic acid (L-phenylalanine methyl ester) amide (SL-1063), a synthetic derivative of 3,4-di(OH)-cinnamate, on the cholesterol metabolism and antioxidant enzyme system was examined in rats. Diets that included either SL-1063 (0.046%, w/w) or lovastatin (0.02%, w/w) as a supplement, plus 1 g cholesterol/100 g diet were fed to rats ad libitum for 5 weeks. The total plasma cholesterol and triglyceride levels were significantly lowered by the SL-1063 supplement compared to the control group. Meanwhile, the levels of plasma HDL-cholesterol and ratio of HDL-cholesterol/total cholesterol (%) were significantly higher in the SL-1063 group than in the control group. However, the lovastatin supplement did not affect the plasma lipid level. The hepatic cholesterol level and 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase activity were significantly lowered in the lovastatin group compared to the SL-1063 group; however, the hepatic triglyceride level did not differ among the groups. The activity of hepatic acyl CoA: cholesterol acyltransferase (ACAT), the enzyme that catalyzes hepatic cholesterol esterification, was significantly lower in the lovastatin and SL-1063 groups than in the control group. Furthermore, the SL-1063 supplement elevated the excretion of fecal sterols. As regards the hepatic antioxidant enzyme system, the superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and glutathione reductase (GR) activities were all significantly higher in the SL-1063 group compared to the control group, whereas only the GR activity was significantly increased by the lovastatin supplement. No marked difference in the GSH levels and glucose-6-phosphate dehydrogenase (G6PD) activities was observed among the groups. The levels of plasma and hepatic thiobarbituric acid reactive substances (TBARS) were lowered by the SL-1063 supplement compared to the control group. Accordingly, the current results suggest that SL-1063, a synthetic derivative of 3,4-di(OH)-cinnamate, is effective in lowering the plasma lipids and improving the antioxidant enzyme system. (c) 2004 Wiley Periodicals, Inc. J Biochem Mol Toxicol 18:279-287, 2004 Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.20036.
机译：3,4-二（OH）-肉桂酸酯的合成衍生物3,4-二（OH）-苯丙酸（L-苯丙氨酸甲酯）酰胺（SL-1063）对胆固醇代谢和抗氧化酶的影响在大鼠中检查了该系统。包括SL-1063（0.046％，w / w）或洛伐他汀（lov％atin）（0.02％，w / w）作为补充的饮食以及1 g胆固醇/ 100 g饮食随意喂养大鼠5周。与对照组相比，SL-1063补充剂可显着降低血浆总胆固醇和甘油三酸酯水平。同时，SL-1063组的血浆HDL-胆固醇水平和HDL-胆固醇/总胆固醇的比率（％）显着高于对照组。但是，洛伐他汀补充剂不会影响血脂水平。与SL-1063组相比，洛伐他汀组的肝胆固醇水平和3-羟-3-甲基戊二酰辅酶A（HMG-CoA）还原酶活性显着降低。然而，两组之间的肝甘油三酯水平没有差异。洛伐他汀和SL-1063组的肝酰基CoA：胆固醇酰基转移酶（ACAT）是一种催化肝胆固醇酯化的酶，其活性明显低于对照组。此外，SL-1063补充剂可增加粪便固醇的排泄。关于肝脏抗氧化酶系统，SL-1063组的超氧化物歧化酶（SOD），过氧化氢酶（CAT），谷胱甘肽过氧化物酶（GSH-Px）和谷胱甘肽还原酶（GR）活性均明显高于对照组。 ，而洛伐他汀补充剂仅显着增加了GR活性。各组之间未观察到GSH水平和6-磷酸葡萄糖脱氢酶（G6PD）活性的显着差异。与对照组相比，SL-1063补充剂降低了血浆和肝硫代巴比妥酸反应性物质（TBARS）的水平。因此，目前的结果表明，SL-1063是3，4-二（OH）-肉桂酸酯的合成衍生物，可有效降低血浆脂质并改善抗氧化酶系统。 （c）2004 Wiley Periodicals，Inc. J Biochem Mol Toxicol 18：279-287，2004在线发布于Wiley InterScience（www.interscience.wiley.com）。 DOI 10.1002 / jbt.20036。

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