Liposome encapsulated vitamin A compounds exhibit greater stability and diminished toxicity.

Singh AK; Das J

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Liposome encapsulated vitamin A compounds exhibit greater stability and diminished toxicity.

机译：脂质体包裹的维生素A化合物显示出更高的稳定性并降低了毒性。

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Absorption and fluorescence studies of retinol (vitamin A alcohol) and retinol palmitate (vitamin A palmitate) intercalated in phosphatidylcholine (PC) liposomes show that these compounds are bound to the lipid bilayer. It is further found that retinol binds liposomes with greater affinity as compared to retinol palmitate. In addition, the delivery of liposome-incorporated retinoids to the blood has also been studied and it is found that these systems reduce blood viscosity and cause less lysis of red blood cells than retinoid compounds not complexed in liposomes.

机译：插在磷脂酰胆碱（PC）脂质体内的视黄醇（维生素A醇）和视黄醇棕榈酸酯（维生素A棕榈酸酯）的吸收和荧光研究表明，这些化合物与脂质双层结合。进一步发现，与棕榈酸视黄醇相比，视黄醇以更大的亲和力结合脂质体。另外，还研究了结合脂质体的类维生素A向血液的递送，并且发现这些系统与未复合在脂质体中的类维生素A化合物相比，降低了血液粘度并引起较少的红细胞裂解。

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来源
《Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena》 |1998年第2期|共8页
作者
Singh AK; Das J;
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原文格式 PDF
正文语种 eng
中图分类生物化学;生物物理学;
关键词
Anticarcinogenic Agents; Vitamin A; Lipid Bilayers; Liposomes; Phosphatidylcholines; 抗致癌药; 维生素A;

机译：Anticarcinogenic Agents;Vitamin A;Lipid Bilayers;Liposomes;Phosphatidylcholines;抗致癌药;维生素A;

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1. Liposome encapsulated vitamin A compounds exhibit greater stability and diminished toxicity. [J] . Singh AK, Das J Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena . 1998,第1a2期

机译：脂质体包裹的维生素A化合物显示出更高的稳定性并降低了毒性。
2. Co-encapsulation of Vitamin C and β-Carotene in liposomes: Storage stability, antioxidant activity, and in vitro gastrointestinal digestion [J] . Liu Xin, Wang Peng, Zou Yu-Xiao, Food research international . 2020,第Octa期

机译：脂质体中维生素C和β-胡萝卜素的共同封装：储存稳定性，抗氧化活性和体外胃肠消化
3. Encapsulation of food waste compounds in soy phosphatidylcholine liposomes: Effect of freeze-drying, storage stability and functional aptitude [J] . Marin D., Aleman A., Montero P., Journal of food engineering . 2018,第APRa期

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4. Cholesterol implications on coconut liposomes encapsulation of beta-carotene and vitamin C [C] . Dwi Hudiyanti, Siti Aminah, Yuanita Hikmahwati Joint Conference on Chemistry . 2019

机译：胆固醇对椰子脂质体的影响β-胡萝卜素和维生素C
5. Blend Uniformity and Vitamin Stability in Dairy-Based Foods Fortified with Lipid-Encapsulated Ferrous Sulfate [D] . ?Lee, Garth Anthony 2020

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6. Ascorbic acid encapsulated into negatively charged liposomes exhibits increased skin permeation retention and enhances collagen synthesis by fibroblasts [O] . Lorena Maione-Silva, Elisandra Gava de Castro, Thais Leite Nascimento, -1

机译：封装在带负电荷脂质体中的抗坏血酸表现出增加的皮肤渗透性保留力并增强成纤维细胞的胶原合成
7. Liposome encapsulated vitamin A compounds exhibit greater stability and diminished toxicity [O] . Anil K. Singhu, Joydip Das 2015

机译：脂质体包封的维生素a化合物表现出更高的稳定性和降低的毒性
8. Complement Activation in Rats by Liposomes and Liposome-Encapsulated Hemoglobin:Evidence for Anti-Lipid Antibodies and Alternative Pathway Activation [R] . Szebeni, J., Wassef, N. M., Spielberg, H., 1994

机译：脂质体和脂质体包裹的血红蛋白对大鼠的补体激活：抗脂质抗体和替代途径激活的证据

Liposome encapsulated vitamin A compounds exhibit greater stability and diminished toxicity.

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