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首页> 外文期刊>Journal of bodywork and movement therapies >Acute repetitive lumbar syndrome: A multi-component insight into the disorder
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Acute repetitive lumbar syndrome: A multi-component insight into the disorder

机译：急性重复性腰椎综合征：对该疾病的多角度见解

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Purpose: Repetitive Lumbar Injury (RLI) is common in individuals engaged in long term performance of repetitive occupational/sports activities with the spine. The triggering source of the disorder, tissues involved in the failure and biomechanical, neuromuscular, and biological processes active in the initiation and development of the disorder, are not known. The purpose is, therefore, to test, using in-vivo feline model and healthy human subjects, the hypothesis that RLI due to prolonged exposure to repetitive lumbar flexion-extension is triggered by an acute inflammation in the viscoelastic tissues and is characterized by lingering residual creep, pronounced changes in neuromuscular control and transient changes in lumbar stability. This report, therefore, is a summary of a lengthy research program consisting of multiple projects. Methods: A series of experimental data was obtained from in-vivo feline groups and normal humans subjected to prolonged cyclic lumbar flexion-extension at high and low loads, high and low velocities, few and many repetitions, as well as short and long in-between rest periods, while recording lumbar displacement and multifidi EMG. Neutrophil and cytokines expression analysis were performed on the dissected feline supraspinous ligaments before loading (control) and 7 h post-loading. A comprehensive, time based model was designed to represent the creep, motor control, tissue biology and stability derived from the experimental data. Results: Prolonged cyclic loading induced creep in the spine, reduced muscular activity, triggered spasms and reduced stability followed, several hours later, by acute inflammation/tissue degradation, muscular hyperexcitability and hyperstability. Fast movement, high loads, many repetitions and short rest periods, triggered the full disorder, whereas low velocities, low loads, long rest and few repetitions, triggered only minor but statistically significant pro-inflammatory tissue degradation and significantly reduced stability. Conclusion: Viscoelastic tissue failure via inflammation is the source of RLI and is also the process which governs the mechanical and neuromuscular characteristic symptoms of the disorder. The experimental data validates the hypothesis and provides insights into the development of potential treatments and prevention.
机译：目的：重复性腰椎损伤（RLI）常见于长期与脊柱进行重复性职业/体育活动的人。尚不清楚该疾病的触发源，参与失败的组织以及在该疾病的发生和发展中活跃的生物力学，神经肌肉和生物过程。因此，目的是使用体内猫科动物模型和健康人类受试者进行测试，该假设是：由于长期暴露于重复性腰椎屈伸而引起的RLI是由粘弹性组织中的急性炎症引发的，其特征是残留的残留物挥之不去蠕变，神经肌肉控制的明显变化以及腰椎稳定性的短暂变化。因此，本报告是一个冗长的研究计划的摘要，该研究计划由多个项目组成。方法：从体内猫科动物和正常人的一系列实验数据中，他们在高和低负荷，高和低速度，很少和很多次重复以及短和长的重复运动中经受长时间的循环腰椎屈伸运动。在休息时间之间，同时记录腰部位移和多肌电图。在加载前（对照）和加载后7 h，对解剖的猫上棘韧带进行中性粒细胞和细胞因子表达分析。设计了一个基于时间的综合模型，以表示从实验数据中得出的蠕变，运动控制，组织生物学和稳定性。结果：长时间的周期性负荷导致脊柱蠕动，肌肉活动减少，痉挛和稳定性降低，几个小时后，急性炎症/组织降解，肌肉过度兴奋和过度稳定。快速运动，高负荷，许多重复和短暂的休息时间触发了完全障碍，而低速，低负荷，长时间休息和很少重复则仅触发了轻微但统计学上显着的促炎性组织降解并显着降低了稳定性。结论：炎症引起的粘弹性组织衰竭是RLI的来源，也是控制该疾病的机械和神经肌肉特征症状的过程。实验数据验证了这一假设，并为潜在治疗和预防的发展提供了见识。

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