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首页> 外文期刊>Drug news & perspectives >Tumor suppressor genes as cancer therapeutics.
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Tumor suppressor genes as cancer therapeutics.

机译：肿瘤抑制基因作为癌症治疗剂。

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摘要

Cancer formation is a multistep process that involves the sequential activation of oncogenes as well as the inactivation of tumor suppressor genes often in the same clone of cells. These genetic changes generate concomitant phenotypic changes in the tumor cells that allow them to continue to survive and expand. Over the past decade a number of genetic alterations in oncogenes and tumor suppressor genes have been identified and extensive research has elucidated their role in cellular growth, differentiation and apoptosis. Targeting tumor suppressor gene pathways is an attractive therapeutic strategy in cancer. This review summarizes the current achievements and future prospects of gene replacement therapy. Methods of gene delivery are described, particularly those that have commonly be used in clinical trials. We discuss efforts to achieve tissue-specific gene delivery and improved efficiency of gene delivery.
机译：癌症的形成是一个多步骤过程，涉及癌基因的顺序激活以及通常在同一细胞克隆中肿瘤抑制基因的失活。这些遗传改变在肿瘤细胞中产生伴随的表型改变，从而使它们能够继续生存和扩展。在过去的十年中，已发现癌基因和肿瘤抑制基因的许多遗传改变，并且广泛的研究阐明了它们在细胞生长，分化和凋亡中的作用。靶向肿瘤抑制基因途径是癌症中有吸引力的治疗策略。这篇综述总结了基因替代疗法的当前成就和未来前景。描述了基因传递的方法，特别是临床试验中常用的方法。我们讨论了实现组织特异性基因传递和提高基因传递效率的努力。

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