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首页> 外文期刊>Journal of Biomechanics >Flow resistance analysis of extracranial-to-intracranial (EC-IC) vein bypass
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Flow resistance analysis of extracranial-to-intracranial (EC-IC) vein bypass

机译：颅外-颅内（EC-IC）静脉旁路的流阻分析

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Although brain bypass surgery has often been selected to treat internal carotid arteries (ICA) which are restricted by aneurysm or artery stenosis, its effectiveness has not been quantitatively evaluated. The purpose of this study is to propose an innovative approach for the evaluation of brain extracranial-to-intracranial (EC-IC) vein bypass surgery, based on the analysis of flow resistance in vein bypasses and within their contralateral carotid arteries through the use of computational fluid dynamics (CFD). Seven patients who underwent vein bypass surgery were examined with the use of high-resolution; computed tomography angiogram (CTA). The reconstructed three-dimensional (3D) geometries were segmented to create CFD calculation domains. Colour Doppler ultrasound (CDU) was used to measure blood flow velocities at the common carotid arteries (CCA), in order to determine inflow conditions. Based on the pipe flow theory, pressure drop was expressed as A?2+B? where A and B represent flow resistance coefficients and ? represents blood mass flow rate. The CFD results revealed that for a healthy ICA, the average values of A and B were 0.013088Pa/(ml/min) 2 and 3.105Pa/(ml/min), respectively. For the vein bypass, an average value of A was 0.0143Pa/(ml/min) 2 and B 3.402Pa/(ml/min), which was approximately that of a healthy ICA. However, in the case of a bypass utilising a venous conduit possessing a large-sized valve or existing size alteration, the flow resistance in that bypass would be higher than those found in the healthy ICA. An imbalance of flow resistances may impose conditions that could predispose hemodynamic failure or distal aneurysm development.
机译：尽管经常选择绕过脑部手术来治疗受动脉瘤或动脉狭窄限制的颈内动脉（ICA），但尚未对其疗效进行定量评估。这项研究的目的是提出一种创新的方法，用于评估颅外-颅内（EC-IC）静脉搭桥手术，其方法是通过分析静脉搭桥及其对侧颈动脉内的流动阻力来进行分析计算流体动力学（CFD）。使用高分辨率对7例行静脉搭桥手术的患者进行了检查。计算机体层摄影血管造影（CTA）。重建的三维（3D）几何形状被分割以创建CFD计算域。彩色多普勒超声（CDU）用于测量颈总动脉（CCA）的血流速度，以确定流入情况。根据管流理论，压降表示为A 2 + B 2。其中A和B代表流阻系数，？代表血液质量流速。 CFD结果表明，对于健康的ICA，A和B的平均值分别为0.013088Pa /（ml / min）2和3.105Pa /（ml / min）。对于静脉搭桥，A的平均值为0.0143Pa /（ml / min）2，B的平均值为3.402Pa /（ml / min），约为健康ICA的平均值。但是，在使用具有大型阀门或现有尺寸变更的静脉导管的旁路的情况下，该旁路中的流阻将高于健康ICA中的流阻。流动阻力的不平衡可能会导致可能导致血液动力学衰竭或远端动脉瘤发展的疾病。

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