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首页> 外文期刊>Journal of Biomechanics >Mechanical analysis of ovine and pediatric pulmonary artery for heart valve stent design
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Mechanical analysis of ovine and pediatric pulmonary artery for heart valve stent design

机译：绵羊和小儿肺动脉用于心脏瓣膜支架设计的力学分析

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Transcatheter heart valve replacement is an attractive and promising technique for congenital as well as acquired heart valve disease. In this procedure, the replacement valve is mounted in a stent that is expanded at the aimed valve position and fixated by clamping. However, for this technique to be appropriate for pediatric patients, the material properties of the host tissue need to be determined to design stents that can be optimized for this particular application. In this study we performed equibiaxial tensile tests on four adult ovine pulmonary artery walls and compared the outcomes with one pediatric pulmonary artery. Results show that the pediatric pulmonary artery was significantly thinner (1.06±0.36. mm (mean±SD)) than ovine tissue (2.85±0.40. mm), considerably stiffer for strain values that exceed the physiological conditions (beyond 50% strain in the circumferential and 60% in the longitudinal direction), more anisotropic (with a significant difference in stiffness between the longitudinal and circumferential directions beyond 60% strain) and presented stronger non-linear stress-strain behavior at equivalent strains (beyond 26% strain) compared to ovine tissue. These discrepancies suggest that stents validated and optimized using the ovine pre-clinical model might not perform satisfactorily in pediatric patients. The material parameters derived from this study may be used to develop stent designs for both applications using computational models.
机译：经导管心脏瓣膜置换术是治疗先天性和后天性心脏瓣膜疾病的一种有吸引力且有希望的技术。在此过程中，替换瓣膜安装在支架中，该支架在目标瓣膜位置扩展并通过夹紧固定。然而，为了使该技术适合于儿科患者，需要确定宿主组织的材料特性以设计可以针对该特定应用进行优化的支架。在这项研究中，我们对四只成年绵羊肺动脉壁进行了等双轴拉伸试验，并将其与一只儿科肺动脉进行了比较。结果表明，小儿肺动脉比羊组织（2.85±0.40.mm）细得多（1.06±0.36.mm（平均值±SD）），对于超过生理条件（超过50％应变）的应变值来说，其硬度更大。相较于60％的应变，纵向和圆周方向的周向应力为60％），各向异性更大（纵向和周向的刚度差异显着超过60％），并且在等效应变（超过26％应变）下表现出更强的非线性应力-应变行为到绵羊组织。这些差异表明，使用绵羊临床前模型验证和优化的支架在小儿患者中可能无法令人满意地工作。这项研究得出的材料参数可用于使用计算模型为两种应用开发支架设计。

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