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首页> 外文期刊>Journal of Biomechanics >The effect of sterilization on the dynamic mechanical properties of paired rabbit cortical bone.
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The effect of sterilization on the dynamic mechanical properties of paired rabbit cortical bone.

机译：灭菌对成对兔皮质骨动态力学性能的影响。

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摘要

The optimal sterilization method for load bearing allografts remains a clinical concern. Recently, supercritical carbon dioxide (SCCO2) treatments have been shown to be capable of terminally sterilizing a range of bacteria and viruses, while preserving the static mechanical properties of cortical bone. This study evaluated the effect of SCCO2 treatment compared with two doses of gamma irradiation, on clinically relevant dynamic mechanical properties of cortical bone. Quasi-static testing was also performed to compare the impairment of treatment. Whole paired adult rabbit humeri were dissected and randomly assigned into either SCCO2 Control, SCCO2 Additive or gamma irradiation at 10 or 25kGy treatment groups. The bones were treated and mechanically tested in three-point bending, with the lefts acting as controls for the treated rights. Maximum load, energy to failure and stiffness were evaluated from static tests. The number of cycles to failure was determined for fatigue at 6-60% of the ultimate load. This study found that SCCO2 treatment with or without additive did not alter static or dynamic mechanical properties. Gamma irradiation had a deleterious dose dependent effect, with statistically significant (p<0.05) reductions in all static mechanical parameters at 25kGy. This effect was increased in fatigue with statistically significant decreases in both the 10 and 25kGy dose groups. This study highlights the expediency of SCCO2 treatment for load bearing bone allograft processing as terminal sterilization can be achieved while maintaining both the quasi-static and dynamic mechanical properties of the graft.
机译：承重同种异体移植物的最佳灭菌方法仍然是临床关注的问题。近来，超临界二氧化碳（SCCO2）处理已被证明能够对多种细菌和病毒进行最终灭菌，同时保留皮质骨的静态机械性能。这项研究评估了SCCO2治疗与两次剂量的γ射线照射相比对皮质骨临床相关动态力学性能的影响。还进行了准静态测试以比较治疗的损害。将完整配对的成年兔肱骨解剖并随机分为10或25kGy治疗组，分为SCCO2对照，SCCO2添加剂或γ射线照射。骨骼经过三点弯曲处理并进行了机械测试，其中左侧用作已处理权利的控制。通过静态测试评估了最大载荷，破坏能量和刚度。确定在最终载荷的6-60％时疲劳的失效循环数。这项研究发现，添加或不添加添加剂的SCCO2处理均不会改变静态或动态机械性能。 γ射线具有有害的剂量依赖性效应，在25kGy时所有静态机械参数的统计学降低均显着（p <0.05）。在10kGy和25kGy剂量组中，这种作用在疲劳中均增加，且统计学上显着降低。这项研究强调了SCCO2处理在承受负荷的同种异体移植过程中的便利性，因为可以在保持移植物的准静态和动态力学性能的同时实现最终灭菌。

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