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首页> 外文期刊>Journal of Biomechanics >Stress distribution and consolidation in cartilage constituents is influenced by cyclic loading and osteoarthritic degeneration
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Stress distribution and consolidation in cartilage constituents is influenced by cyclic loading and osteoarthritic degeneration

机译：软骨成分中的应力分布和固结受循环载荷和骨关节炎变性的影响

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摘要

The understanding of load support mechanisms in cartilage has evolved with computational models that better mimic the tissue ultrastructure. Fibril-reinforced poroelastic models can reproduce cartilage behaviour in a variety of test conditions and can be used to model tissue anisotropy as well as assess stress and pressure partitioning to the tissue constituents. The goal of this study was to examine the stress distribution in the fibrillar and non-fibrillar solid phase and pressure in the fluid phase of cartilage in axisymmetric models of a healthy and osteoarthritic hip joint. Material properties, based on values from the literature, were assigned to the fibrillar and poroelastic components of cartilage and cancellous and subchondral compact bone regions. A cyclic load representing walking was applied for 25 cycles. Contact stresses in the fibrillar and non-fibrillar solid phase supported less than 1% of the contact force and increased only minimally with load cycles. Simulated proteoglycan depletion increased stresses in the radial and tangential collagen fibrils, whereas fibrillation of the tangential fibrils resulted in increased compressive stress in the non-fibrillar component and tensile stress in the radial fibrils. However neither had an effect on fluid pressure. Subchondral sclerosis was found to have the largest effect, resulting in increased fluid pressure, non-fibrillar compressive stress, tangential fibril stress and greater cartilage consolidation. Subchondral bone stiffening may play an important role in the degenerative cascade and may adversely affect tissue repair and regeneration treatments.
机译：通过更好地模仿组织超微结构的计算模型，对软骨中的负载支持机制有了更深入的了解。原纤维增强的多孔弹性模型可以在各种测试条件下重现软骨行为，并且可以用于对组织各向异性进行建模以及评估对组织成分的压力和压力分配。这项研究的目的是在健康和骨关节炎髋关节的轴对称模型中检查软骨的原纤维和非原纤维固相中的应力分布以及软骨流体相中的压力。根据文献中的值，将材料属性分配给软骨，松质和软骨下致密骨区域的纤维状和多孔弹性成分。施加代表步行的循环载荷25个循环。纤维状和非纤维状固相中的接触应力仅支持不到1％的接触力，并且仅随负载循环而最小地增加。模拟的蛋白聚糖消耗增加了径向和切向胶原原纤维中的应力，而切向原纤维的原纤化导致非原纤维成分中的压缩应力增加和径向原纤维中的拉伸应力增加。但是，它们都没有影响流体压力。发现软骨下硬化具有最大的作用，导致流体压力增加，非原纤维压应力，切向原纤维应力和更大的软骨固结。软骨下骨变硬可能在变性级联中起重要作用，并且可能对组织修复和再生治疗产生不利影响。

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