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首页> 外文期刊>Journal of Biomechanics >Unraveling the relationship between arterial flow and intra-aneurysmal hemodynamics
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Unraveling the relationship between arterial flow and intra-aneurysmal hemodynamics

机译：阐明动脉血流与动脉瘤内血流动力学之间的关系

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Arterial flow rate affects intra-aneurysmal hemodynamics but it is not clear how their relationship is. This uncertainty hinders the comparison among studies, including clinical evaluations, like a pre- and post-treatment status, since arterial flow rates may differ at each time acquisition. The purposes of this work are as follows: (1) To study how intra-aneurysmal hemodynamics changes within the full physiological range of arterial flow rates. (2) To provide characteristic curves of intra-aneurysmal velocity, wall shear stress (WSS) and pressure as functions of the arterial flow rate. Fifteen image-based aneurysm models were studied using computational fluid dynamics (CFD) simulations. The full range of physiological arterial flow rates reported in the literature was covered by 11 pulsatile simulations. For each aneurysm, the spatiotemporal-averaged blood flow velocity, WSS and pressure were calculated. Spatiotemporal-averaged velocity inside the aneurysm linearly increases as a function of the mean arterial flow (minimum R-2 > 0.963). Spatiotemporal-averaged WSS and pressure at the aneurysm wall can be represented by quadratic functions of the arterial flow rate (minimum R-2 > 0.996). Quantitative characterizations of spatiotemporal-averaged velocity, WSS and pressure inside cerebral aneurysms can be obtained with respect to the arterial flow rate. These characteristic curves provide more information of the relationship between arterial flow and aneurysm hemodynamics since the full range of arterial flow rates is considered. Having these curves, it is possible to compare experimental studies and clinical evaluations when different flow conditions are used. (C) 2015 Elsevier Ltd. All rights reserved.
机译：动脉流速会影响动脉瘤内的血流动力学，但尚不清楚它们之间的关系。这种不确定性阻碍了研究之间的比较，包括临床评估，如治疗前和治疗后状态，因为每次采集时动脉流速可能不同。这项工作的目的如下：（1）研究动脉瘤全血流范围内动脉瘤内血流动力学的变化。 （2）提供动脉内流速，壁切应力（WSS）和压力随动脉流速变化的特征曲线。使用计算流体动力学（CFD）模拟研究了十五个基于图像的动脉瘤模型。 11种搏动模拟涵盖了文献中报道的全部生理动脉流速。对于每个动脉瘤，计算时空平均血流速度，WSS和压力。动脉瘤内的时空平均速度随平均动脉血流量线性增加（最低R-2> 0.963）。时空平均的WSS和动脉瘤壁处的压力可由动脉流速的二次函数表示（最小R-2> 0.996）。可以获取相对于动脉流速的时空平均速度，WSS和脑动脉瘤内压力的定量特征。这些特征曲线提供了更多有关动脉血流与动脉瘤血流动力学之间关系的信息，因为考虑了整个范围的动脉血流速度。通过使用这些曲线，可以在使用不同流动条件时比较实验研究和临床评估。 （C）2015 Elsevier Ltd.保留所有权利。

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