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首页> 外文期刊>Journal of Biomechanics >Older asymptomatic women exhibit patterns of thumb carpometacarpal joint space narrowing that precede changes associated with early osteoarthritis
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Older asymptomatic women exhibit patterns of thumb carpometacarpal joint space narrowing that precede changes associated with early osteoarthritis

机译：无症状的老年妇女在与早期骨关节炎相关的变化之前表现出拇指腕掌关节间隙变窄的模式

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In small joints, where cartilage is difficult to image and quantify directly, three-dimensional joint space measures can be used to gain insight into potential joint pathomechanics. Since the female sex and older age are risk factors for carpometacarpal (CMC) joint osteoarthritis (OA), the purpose of this in vivo computed tomography (CT) study was to determine if there are any differences with sex, age, and early OA in the CMC joint space. The thumbs of 66 healthy subjects and 81 patients with early stage CMC OA were scanned in four range-of-motion, three functional-task, and one neutral positions. Subchondral bone-to-bone distances across the trapezial and metacarpal articular surfaces were computed for all the positions. The joint space area, defined as the articular surface that is less than 1.5 mm from the mating bone, was used to assess joint space. A larger joint space area typically corresponds to closer articular surfaces, and therefore a narrower joint space. We found that the joint space areas are not significantly different between healthy young men and women. Trends indicated that patients with early stage OA have larger CMC joint space areas than healthy subjects of the same age group and that older healthy women have larger joint space areas than younger healthy women. This study suggests that aging in women may lead to joint space narrowing patterns that precede early OA, which is a compelling new insight into the pathological processes that make CMC OA endemic to women. (C) 2015 Elsevier Ltd. All rights reserved.
机译：在软骨难以直接成像和量化的小关节中，可以使用三维关节空间测量来了解潜在的关节病理机制。由于女性和年龄较大的人是腕掌关节（CMC）关节骨关节炎（OA）的危险因素，因此本体内计算机断层扫描（CT）研究的目的是确定是否存在性别，年龄和早期OA差异。 CMC联合空间。在四个运动范围，三个功能任务和一个中性位置中对66位健康受试者和81位早期CMC OA患者的拇指进行了扫描。计算所有位置的跨梯骨和掌骨关节面的软骨下骨到骨的距离。关节间隙区域定义为距交配骨小于1.5毫米的关节表面，用于评估关节间隙。较大的关节间隙区域通常对应于较近的关节表面，因此较窄的关节间隙。我们发现健康的青年男女之间的关节间隙区域没有显着差异。趋势表明，患有早期OA的患者比相同年龄组的健康受试者具有更大的CMC关节间隙区域，并且年龄较大的健康女性比年轻健康的女性具有更大的关节间隙区域。这项研究表明，女性衰老可能导致早期OA之前的关节空间狭窄模式，这是使CMC OA普遍存在于女性的病理过程的一种令人信服的新见解。 （C）2015 Elsevier Ltd.保留所有权利。

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