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首页> 外文期刊>Journal of Biomechanics >The developing shoulder has a limited capacity to recover after a short duration of neonatal paralysis
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The developing shoulder has a limited capacity to recover after a short duration of neonatal paralysis

机译：发育中的肩部在短期瘫痪后恢复能力有限

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摘要

Mechanical stimuli are required for the proper development of the musculoskeletal system. Removal of muscle forces during fetal or early post-natal timepoints impairs the formation of bone, tendon, and their attachment (the enthesis). The goal of the current study was to examine the capacity of the shoulder to recover after a short duration of neonatal rotator cuff paralysis, a condition mimicking the clinical condition neonatal brachial plexus palsy. We asked if reapplication of muscle load to a transiently paralyzed muscle would allow for full recovery of tissue properties. CD-1 mice were injected with botulinum toxin A to paralyze the supraspinatus muscle from birth through 2 weeks and subsequently allowed to recover. The biomechanics of the enthesis was determined using tensile testing and the morphology of the shoulder joint was determined using microcomputed tomography and histology. A recovery period of at least 10 weeks was required to achieve control properties, demonstrating a limited capacity of the shoulder to recover after only two weeks of muscle paralysis. Although care must be taken when extrapolating results from an animal model to the human condition, the results of the current study imply that treatment of neonatal brachial plexus palsy should be aggressive, as even short periods of paralysis could lead to long-term deficiencies in enthesis biomechanics and shoulder morphology.
机译：肌肉骨骼系统的正常发育需要机械刺激。在胎儿或产后早期时间点去除肌肉力量会损害骨骼，肌腱及其附着（形成）的形成。当前研究的目的是检查在短期内新生儿肩袖麻痹后的肩部恢复能力，这种情况类似于临床上的新生儿臂丛神经麻痹。我们询问将肌肉负荷重新施加到短暂性瘫痪的肌肉是否可以使组织特性完全恢复。给CD-1小鼠注射肉毒杆菌毒素A，以使其从出生到两周使脊髓上肌麻痹，然后恢复。使用拉伸试验确定该生物体的生物力学，并使用计算机断层扫描和组织学方法确定肩关节的形态。要达到控制特性，至少需要10周的恢复期，这表明仅两周的肌肉麻痹后肩膀恢复能力有限。尽管将动物模型的结果推算到人体状况时必须小心，但当前的研究结果暗示，新生儿臂丛神经麻痹的治疗应积极，因为即使是短时间的瘫痪也可能导致长期的身体缺陷生物力学和肩部形态。

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