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首页> 外文期刊>Journal of Biomechanics >NACOB presentation Keynote lecture. Cancellous bone biomechanics. North American Congress on Biomechanics.
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NACOB presentation Keynote lecture. Cancellous bone biomechanics. North American Congress on Biomechanics.

机译：NACOB演讲主题演讲。松质骨生物力学。北美生物力学大会。

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Cancellous bone is both a biological and a mechanical structure. The interaction between these two aspects of cancellous bone is sufficiently strong that understanding the mechanical properties of the tissue is not possible without consideration of the biology. This manuscript is a mathematical expansion of a portion of the first author's Keynote lecture at the 1998 NACOB presentation. The cellular activity of cancellous bone proceeds in part by the transport of metabolites between trabecular hard tissue and marrow. The anatomical observation is that human trabeculae are seldom internally served by a blood supply, suggesting that the transport mechanisms for trabecular survival are diffusion and a collection of mechanisms for active transport of metabolites independent of blood flow. It will be demonstrated that metabolite transport by diffusion can explain two notable empirical relationships for bone: (a) the close relationship between the bone surface and the bone volume, and (b) the exponential decline in the bone volume fraction during periods of mechanical disuse. A mathematical model is also developed showing how mechanical loading can effect bone volume fraction by increasing metabolite transport between the tissue compartments.
机译：松质骨既是生物结构又是机械结构。松质骨的这两个方面之间的相互作用足够强，以至于不考虑生物学就不可能了解组织的机械特性。该手稿是1998年NACOB演讲中第一作者主题演讲的一部分的数学扩展。松质骨的细胞活性部分地通过小梁硬组织和骨髓之间的代谢物运输来进行。解剖学观察表明，小梁在内部很少由血液供应，这表明小梁存活的运输机制是扩散，并且是代谢产物主动运输的机制的独立于血流的集合。可以证明，通过扩散的代谢物运输可以解释骨骼的两个显着的经验关系：（a）骨骼表面与骨骼体积之间的紧密关系，以及（b）在机械停用期间骨骼体积分数的指数下降。还建立了一个数学模型，显示了机械负荷如何通过增加组织隔间之间的代谢产物运输来影响骨体积分数。

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