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首页> 外文期刊>Journal of Biomechanics >Investigation of In Vivo skin stiffness anisotropy in breast cancer related lymphoedema
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Investigation of In Vivo skin stiffness anisotropy in breast cancer related lymphoedema

机译：乳腺癌相关淋巴水肿的体内皮肤僵硬各向异性研究

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There is a limited range of suitable measurement techniques for detecting and assessing breast cancer related lymphoedema (BCRL). This study investigated the suitability of using skin stiffness measurements, with a particular focus on the variation in stiffness with measurement direction (known as anisotropy). In addition to comparing affected tissue with the unaffected tissue on the corresponding site on the opposite limb, volunteers without BCRL were tested to establish the normal variability in stiffness anisotropy between these two corresponding regions of skin on each opposite limb. Multi -directional stiffness was measured with an Extensometer, within the higher stiffness region that skin typically displays at high applied strains, using a previously established protocol developed by the authors. Healthy volunteers showed no significant difference in anisotropy between regions of skin on opposite limbs (mean decrease of 4.7 +/- 2.5% between non-dominant and dominant arms), whereas BCRL sufferers showed a significant difference between limbs (mean decrease of 51.0+/-16.3% between unaffected and affected arms). A large difference in anisotropy was apparent even for those with recent onset of the condition, indicating that the technique may have potential to be useful for early detection. This difference also appeared to increase with duration since onset. Therefore, measurement of stiffness anisotropy has potential value for the clinical assessment and diagnosis of skin conditions such as BCRL. The promising results justify a larger study with a larger number of participants. (C) 2015 Elsevier Ltd. All rights reserved.
机译：用于检测和评估与乳腺癌相关的淋巴水肿（BCRL）的合适的测量技术范围有限。这项研究调查了使用皮肤刚度测量的适用性，尤其关注刚度随测量方向的变化（称为各向异性）。除了比较患肢组织和相对肢体相应部位上未受影响的组织外，还对没有BCRL的志愿者进行了测试，以建立每个相对肢体的这两个相应皮肤区域之间僵硬各向异性的正常变异性。使用由作者开发的先前建立的协议，使用引伸计在皮肤通常在较高的施加应变下表现出的较高刚度区域内测量多向刚度。健康的志愿者在两肢的皮肤区域之间的各向异性没有显着差异（非优势臂和优势臂之间的均值下降了4.7 +/- 2.5％），而BCRL患者在肢体之间的各向异性显着（均值下降了51.0 + /未受影响和受影响的武器之间的-16.3％）。各向异性的差异也很明显，即使对于那些刚开始发病的人也是如此，这表明该技术可能具有用于早期发现的潜力。自发病以来，这种差异似乎也随着持续时间而增加。因此，刚度各向异性的测量对于临床评估和诊断皮肤状况（如BCRL）具有潜在价值。令人鼓舞的结果证明了一项有大量参与者的大型研究的合理性。 （C）2015 Elsevier Ltd.保留所有权利。

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