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首页> 外文期刊>Journal of Biomechanics >Functional assessment in the rat by ground reaction forces.
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Functional assessment in the rat by ground reaction forces.

机译：通过地面反作用力在大鼠中进行功能评估。

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Although the rat sciatic nerve model is used extensively in the investigation of repair techniques, and a variety of evaluation methods utilized to assess the results, a means to measure directly and accurately the return of function in these animals is absent. Histologic, histomorphometric, and electrophysiologic methods can be reliable indicators of nerve regeneration but do not correlate to functional recovery. The purposes of this study were to develop apparatus to continuously measure ground reaction forces (GRF) and use GRF parameters in the assessment of gait parameters in normal rats preoperatively and following peripheral nerve severance and repair. Three neurorrhaphy methods: direct sciatic nerve repair, direct tibial nerve repair and double sciatic nerve repair simulating autograft, as well as a non-repaired tibial nerve transection were evaluated. The testing apparatus was designed to measure the spontaneous and voluntary effort of the rat with objective data. Three orthogonal components - vertical, craniocaudal (braking and propulsion), and mediolateral - of the ground reaction force were measured. Preoperative data showed that vertical forces were comparable among the four limbs but propulsion and braking forces displayed significant differences. At 12 weeks, functional recovery was most evident in the direct tibial nerve repair group and absent in the non-repaired tibial defect group. Direct sciatic nerve repairs and sciatic nerve grafts resulted in lesser degrees of improvement. Results indicated that the propulsive force is the optimal GRF parameter for evaluating recovery of useful function.
机译：尽管大鼠坐骨神经模型广泛用于修复技术的研究中，并且使用多种评估方法来评估结果，但是缺少直接和准确地测量这些动物功能恢复的方法。组织学，组织形态学和电生理学方法可以作为神经再生的可靠指标，但与功能恢复无关。这项研究的目的是开发一种可以连续测量地面反作用力（GRF）的仪器，并在术前以及周围神经切断和修复后使用GRF参数评估正常大鼠的步态参数。评估了三种神经外科学方法：模拟自体移植的坐骨神经直接修复，胫骨神经直接修复和坐骨神经双修复以及未修复的胫骨神经横断。该测试仪器旨在通过客观数据来测量大鼠的自发性和自愿性努力。测量了地面反作用力的三个正交分量-垂直，颅尾（制动和推进）和中外侧-。术前数据显示，四个肢体的垂直力相当，但推进力和制动力却存在显着差异。在第12周时，在胫骨直接神经修复组中功能恢复最为明显，而在未修复的胫骨缺损组中则没有。直接坐骨神经修复和坐骨神经移植导致改善程度较轻。结果表明，推进力是评估有用功能恢复的最佳GRF参数。

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