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首页> 外文期刊>Journal of Biomechanics >Estimation of bone mineral density and architectural parameters of the distal radius in hemodialysis patients using peripheral quantitative computed tomography
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Estimation of bone mineral density and architectural parameters of the distal radius in hemodialysis patients using peripheral quantitative computed tomography

机译：使用外周定量计算机断层扫描估计血液透析患者的骨矿物质密度和radius骨远端的结构参数

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We analyzed bone changes in a series of hemodialysis patients followed up for a maximum of 299 months by assessing bone mineral density (BMD) and architectural parameters of the distal radius using peripheral quantitative computed tomography (pQCT), and determined the predictors of skeletal changes in these patients.No significant differences in trabecular BMD (BMDT) were found compared with BMDT of the normal control. In contrast, cortical BMD (BMDC) was significantly decreased compared with BMDC, of the normal controls.Hemodialysis patients had significantly lower values for cortical bone area, cortical thickness, moment of inertia, and polar moment of inertia than the age-matched controls.From single and multiple regression analysis, the most significant predictor of metabolic bone disease in these cases was found to be duration of hemodialysis. In addition, increases in serum alkaline phosphatase and intact parathyroid hormone in secondary hyperparathyroidism were found to correlate with a decrease in pQCT values in cortical bone; as such, these increases were also found to be a predictive.The present study confirms that the reduction in both BMDC and architectural parameters in hemodialysis patients occurs partly because of prolonged hemodialysis and secondary hyperparathyroidism. In addition, immobilization, dietary factors, daily intake of calcium or vitamin D, and so on must be taken into account when clarifying the causes of skeletal complications resulting from hemodialysis. (C) 2003 Published by Elsevier Ltd.
机译：我们通过评估外周血定量计算机断层扫描（pQCT）的骨矿物质密度（BMD）和远端radius骨的建筑参数，分析了一系列血液透析患者的骨质变化，最长随访299个月，并确定了这些骨质疏松症的骨骼变化预测因子与正常对照组的BMDT相比，小梁BMD（BMDT）没有发现显着差异。相比之下，正常对照组的皮质BMD（BMDC）明显低于BMDC。血液透析患者的皮质骨面积，皮质厚度，惯性矩和极地惯性矩值均低于年龄匹配的对照组。通过单次和多次回归分析，发现在这些情况下，代谢性骨病的最重要预测因子是血液透析的持续时间。此外，发现继发性甲状旁腺功能亢进症患者血清碱性磷酸酶和完整甲状旁腺激素的增加与皮质骨中pQCT值的降低有关。因此，这些增加也被认为是可以预测的。本研究证实，血液透析患者的BMDC和结构参数的降低部分是由于血液透析时间延长和继发性甲状旁腺功能亢进。另外，在阐明血液透析引起的骨骼并发症的原因时，必须考虑固定，饮食因素，钙或维生素D的每日摄入量等。 （C）2003年由Elsevier Ltd.出版

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