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首页> 外文期刊>Journal of Biomechanics >An ultrasound-based method for determining pulse wave velocity in superficial arteries
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An ultrasound-based method for determining pulse wave velocity in superficial arteries

机译：基于超声的浅表动脉脉搏波速度测定方法

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In this paper, we present a method for estimating local pulse wave velocity (PWV) solely from ultrasound measurements: the area-flow (QA) method. With the QA method, PWV is estimated as the ratio between change in flow and change in cross-sectional area (PWV = dQ/dA) during the reflection-free period of the cardiac cycle. In four anaesthetized dogs and 21 human subjects (age 2374) we measured the carotid flow and cross-sectional area non-invasively by ultrasound. As a reference method we used the Bramwell-Hill (BH) equation which estimates PWV from pulse pressure and cross-sectional area. Additionally, we therefore measured brachial pulse pressure by oscillometry in the human subjects, and central aortic pulse pressure by micro-manometry in the dogs. As predicted by the pressure dependency of arterial stiffness, the estimated PWV decreased when the aortic pressure was lowered in two of the dogs. For the human subjects, the QA and BH estimates were correlated (R = 0.43, p < 0.05) and agreed on average (mean difference of -0.14 m/s). The PWV by the BH method increased with age (p < 0.01) whereas the PWV by the QA method tended to increase with age (p < 0.1). This corresponded to a larger residual variance (residual = deviation of the estimated PWV from the regression line) for the QA method than for the BH method, indicating different precisions for the two methods. This study illustrates that the simple equation PWV = dQ/dA gives estimates correlated to the PWV of the reference method. However, improvements in the basic measurements seem necessary to increase the precision of the method. (C) 2004 Elsevier Ltd. All rights reserved.
机译：在本文中，我们提出了一种仅通过超声测量来估计局部脉搏波速度（PWV）的方法：面积流（QA）方法。使用QA方法，可以将PWV估算为心动周期无反射期间流量变化与横截面积变化之间的比率（PWV = dQ / dA）。在四只麻醉狗和21位人类受试者（年龄2374）中，我们通过超声非侵入性地测量了颈动脉血流和横截面积。作为参考方法，我们使用了Bramwell-Hill（BH）方程，该方程根据脉冲压力和横截面积估算PWV。此外，因此，我们通过示波法测量了人类受试者的肱动脉脉压，并通过了狗的显微测压法测量了中枢主动脉脉压。如动脉僵硬度的压力依赖性所预测的那样，当两只狗的主动脉压力降低时，估计的PWV降低。对于人类受试者，QA和BH估计值相互关联（R = 0.43，p <0.05），并且平均同意（平均差为-0.14 m / s）。 BH方法的PWV随年龄增长（p <0.01），而QA方法的PWV随年龄增长（p <0.1）。对于QA方法，这对应于比BH方法更大的残差（残差=估计的PWV与回归线的偏差），表明两种方法的精度不同。这项研究表明，简单方程PWV = dQ / dA给出了与参考方法的PWV相关的估计。但是，似乎有必要对基本测量进行改进以提高该方法的精度。 （C）2004 Elsevier Ltd.保留所有权利。

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