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首页> 外文期刊>Journal of Biomechanics >The flexural rigidity of the aortic valve leaflet in the commissural region.
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The flexural rigidity of the aortic valve leaflet in the commissural region.

机译：主动脉瓣小叶在连合区域的抗弯刚度。

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摘要

Flexure is a major deformation mode of the aortic valve (AV) leaflet, particularly in the commissural region where the upper portion of the leaflet joins the aortic root. However, there are no existing data known on the mechanical properties of leaflet in the commissural region. To address this issue, we quantified the effective stiffness of the commissural region using a cantilever beam method. Ten specimens were prepared, with each specimen flexed in the direction of natural leaflet motion (forward) and against the natural motion (reverse). At a flexure angle (phi) of 30 degrees , the effective forward direction modulus E was 42.63+/-4.44 kPa and the reverse direction E was 75.01+/-14.53 kPa (p=0.049). Further, E-phi response was linear (r(2) approximately 0.9) in both flexural directions. Values for dE/dphi were -2.24+/-0.6 kPa/ degrees and -1.90+/-0.3 kPa/ degrees in the forward and reverse directions, respectively (not statistically different, p=0.424), indicating a consistent decrease in stiffness with increased flexure. In comparison, we have reported that the effective tissue stiffness of AV leaflet belly region was 150-200 kPa [Merryman, W.D., Huang, H.Y.S., Schoen, F.J., Sacks, M.S. (2006). The effects of cellular contraction on AV leaflet flexural stiffness. Journal of Biomechanics 39 (1), 88-96], which was also independent of direction and amount of flexure. Histological studies of the commissure region indicated that tissue buckling was a probable mechanism for decrease in E with increasing flexure. The observed change in E with flexural angle in the commissural region is a subtle aspect of valve function. From a valve design perspective, these findings can be used as design criteria in fabricating prosthetic devices AV resulting in better functional performance.
机译：挠曲是主动脉瓣（AV）小叶的主要变形模式，特别是在小叶的上部与主动脉根连接的连合区域。但是，没有关于连合区域内小叶的机械性能的现有数据。为了解决这个问题，我们使用悬臂梁法量化了连合区域的有效刚度。制备了十个样本，每个样本都沿自然的小叶运动方向（向前）和逆着自然运动（反向）弯曲。在挠曲角φ为30度时，有效前向模量E为42.63 +/- 4.44kPa，而反向E为75.01 +/- 14.53kPa（p ＝ 0.049）。此外，E-phi响应在两个弯曲方向上都是线性的（r（2）约为0.9）。 dE / dphi值在正向和反向分别为-2.24 +/- 0.6 kPa /度和-1.90 +/- 0.3 kPa /度（无统计学差异，p = 0.424），表明刚度随着弯曲增加。相比之下，我们已经报道了AV小叶腹部区域的有效组织刚度为150-200 kPa [Merryman，W.D.，Huang，H.Y.S.，Schoen，F.J.，Sacks，M.S. （2006）。细胞收缩对AV小叶弯曲刚度的影响。 Journal of Biomechanics 39（1），88-96]，它也与弯曲的方向和量无关。对连合区域的组织学研究表明，组织屈曲是随弯曲增加而E降低的可能机制。在连合区域观察到的E随弯曲角的变化是阀门功能的一个细微方面。从瓣膜设计的角度来看，这些发现可以用作制造假体设备AV的设计标准，从而获得更好的功能性能。

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