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首页> 外文期刊>Journal of Biomechanics >Effects of administration of transforming growth factor (TGF)-beta1 and anti-TGF-beta1 antibody on the mechanical properties of the stress-shielded patellar tendon.
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Effects of administration of transforming growth factor (TGF)-beta1 and anti-TGF-beta1 antibody on the mechanical properties of the stress-shielded patellar tendon.

机译：施用转化生长因子（TGF）-β1和抗TGF-β1抗体对应力屏蔽pa骨肌腱力学性能的影响。

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Previous studies have shown that, in the stress-shielded patellar tendon, the mechanical properties of the tendon were dramatically reduced and TGF-beta was over-expressed in tendon fibroblasts. In the present study, therefore, we tested two supportive hypotheses using 40 rabbits: One was that an application of TGF-beta1 might significantly increase the tensile strength and the tangent modulus of the stress-shielded patellar tendon. The other one was that an administration of anti-TGF-beta1 antibody might significantly reduce the mechanical properties of the stress-shielded patellar tendon. In the results, an application of 4-ng TGF-beta1 significantly increased the tangent modulus of the stress-shielded patellar tendon at 3 weeks (p = 0.019), compared with the sham treatment. Concerning the tensile strength, the 4-ng TGF-beta1 application increased the average value, but a statistical significance was not reached. An application of 50-microg anti-TGF-beta1 antibody significantly reduced the tangent modulus and the tensile strength of the stress-shielded patellar tendon at 3 weeks (p = 0.0068 and p = 0.0355), compared with the sham treatment. Because the stress-shielding treatment used in this study dramatically reduces the tangent modulus and the tensile strength of the patellar tendon, the present study suggested that an administration of TGF-beta1 weakly but significantly inhibited the reduction of the mechanical properties of the stress-shielded patellar tendon, and that inactivation of TGF-beta1 with its antibody significantly enhanced the reduction of the mechanical properties that occurs in the stress-shielded patellar tendon. These results suggested that TGF-beta1 plays an important role in remodeling of the stress-shielded patellar tendon.
机译：先前的研究表明，在应力屏蔽pa骨肌腱中，肌腱的力学性能显着降低，而TGF-β在肌腱成纤维细胞中过表达。因此，在本研究中，我们使用40只兔子测试了两种支持性假设：一种是TGF-β1的应用可能会显着增加应力屏蔽pa骨腱的拉伸强度和切线模量。另一个是抗TGF-β1抗体的使用可能会显着降低应力屏蔽ed骨肌腱的机械性能。结果显示，与假手术相比，应用4 ngTGF-β1可以显着增加受应力保护的pa骨腱在3周时的切线模量（p = 0.019）。关于拉伸强度，使用4-ng TGF-beta1可以提高平均值，但未达到统计学意义。与假手术相比，使用50微克抗TGF-β1抗体可在3周时显着降低切应力模量的pa骨腱的切线模量和拉伸强度（p = 0.0068和p = 0.0355）。由于本研究中使用的应力屏蔽处理显着降低了tell骨腱的切线模量和抗张强度，因此本研究表明，TGF-β1的给药较弱，但显着抑制了应力屏蔽机械性能的降低antibody骨肌腱和TGF-β1的抗体失活显着增强了应力屏蔽pa骨肌腱的机械性能的降低。这些结果表明，TGF-beta1在应力屏蔽pa骨肌腱的重塑中起重要作用。

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