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首页> 外文期刊>Journal of Biomechanics >Non-Newtonian effects of blood flow on hemodynamics in distal vascular graft anastomoses.
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Non-Newtonian effects of blood flow on hemodynamics in distal vascular graft anastomoses.

机译：血液流动对远端血管移植物吻合口血流动力学的非牛顿效应。

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Non-Newtonian fluid flow in a stenosed coronary bypass is investigated numerically using the Carreau-Yasuda model for the shear thinning behavior of the blood. End-to-side coronary bypass anastomosis is considered in a simplified model geometry where the host coronary artery has a 75% severity stenosis. Different locations of the bypass graft to the stenosis and different flow rates in the graft and in the host artery are studied. Particular attention is given to the non-Newtonian effect of the blood on the primary and secondary flow patterns in the host coronary artery and the wall shear stress (WSS) distribution there. Interaction between the jet flow from the stenosed artery and the flow from the graft is simulated by solving the three-dimensional Navier-Stokes equation coupled with the non-Newtonian constitutive model. Results for the non-Newtonian flow, the Newtonian flow and the rescaled Newtonian flow are presented. Significant differences in axial velocity profiles, secondary flow streamlines and WSS between the non-Newtonian and Newtonian fluid flows are revealed. However, reasonable agreement between the non-Newtonian and the rescaled Newtonian flows is found. Results from this study support the view that the residual flow in a partially occluded coronary artery interacts with flow in the bypass graft and may have significant hemodynamic effects in the host vessel downstream of the graft. Non-Newtonian property of the blood alters the flow pattern and WSS distribution and is an important factor to be considered in simulating hemodynamic effects of blood flow in arterial bypass grafts.
机译：使用Carreau-Yasuda模型，对狭窄的冠状动脉旁路中的非牛顿流体流动进行了数值研究，以研究血液的剪切稀化行为。在简化的模型几何中考虑端到端冠状动脉旁路吻合术，其中主冠状动脉狭窄程度为75％。研究了旁路移植物狭窄的不同位置以及移植物和宿主动脉中的不同流速。特别注意血液对宿主冠状动脉一级和二级血流模式的非牛顿效应以及那里的壁切应力（WSS）分布。通过求解三维Navier-Stokes方程和非牛顿本构模型，模拟了来自狭窄动脉的射流与来自移植物的射流之间的相互作用。给出了非牛顿流，牛顿流和重新缩放的牛顿流的结果。揭示了非牛顿流体和牛顿流体之间的轴向速度分布，次要流线和WSS的显着差异。但是，在非牛顿流和重新缩放的牛顿流之间找到了合理的一致。这项研究的结果支持以下观点：部分阻塞的冠状动脉中的残留血流与旁路移植物中的血流相互作用，并且可能在移植物下游的宿主血管中产生重大的血液动力学影响。血液的非牛顿特性会改变流动模式和WSS分布，并且是模拟动脉旁路移植术中血流的血液动力学效应时要考虑的重要因素。

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