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首页> 外文期刊>Journal of biomedical materials research, Part A >A comparative study of the remodeling and integration of a novel AuNP-tissue scaffold and commercial tissue scaffolds in a porcine model
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A comparative study of the remodeling and integration of a novel AuNP-tissue scaffold and commercial tissue scaffolds in a porcine model

机译：猪模型中新型AuNP组织支架和商用组织支架的重塑和整合的比较研究

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摘要

The extracellular matrices of a variety of human and animal tissues have been utilized as scaffold materials for soft tissue applications including hernia repair, dermal grafts, and tendon, ligament, and cartilage reconstruction. While these biological scaffolds are expected to demonstrate superior tissue integration, there is very little evidence documenting the properties and behavior of these materials in vivo. This in vivo study investigated four biological scaffolds: two commercially available (a moderately crosslinked scaffold and a noncrosslinked scaffold) and two novel porcine diaphragm biological scaffolds (one with and one without the incorporation of gold nanoparticles). The scaffolds were implanted in a porcine model and evaluated over 1, 3, and 6 months. The moderately crosslinked scaffolds demonstrated the least cellular infiltration and evidence of fibrosis. The noncrosslinked scaffolds demonstrated the greatest cellular infiltration, but these scaffolds were delaminated and exhibited a rapid loss of integrity. The porcine diaphragm scaffolds with and without nanoparticles showed evidence of tissue remodeling and cellular infiltration, with no evidence of encapsulation. While there were no significant differences in the performance of the two novel scaffolds, the gold nanoparticle scaffold typically exhibited higher cellular infiltration. This study demonstrated the potential biocompatibility of a gold nanoparticle-tissue scaffold.
机译：各种人类和动物组织的细胞外基质已被用作软组织应用的支架材料，包括疝气修复，真皮移植，肌腱，韧带和软骨重建。尽管这些生物支架有望表现出优异的组织整合性，但很少有证据证明这些材料在体内的特性和行为。这项体内研究研究了四种生物支架：两种市售（中等交联的支架和非交联的支架）和两种新型的猪diaphragm膜生物支架（一种带有金纳米粒子，一种带有金纳米粒子）。将支架植入猪模型中，并在1、3和6个月内进行评估。中度交联的支架表现出最少的细胞浸润和纤维化的证据。非交联的支架表现出最大的细胞浸润，但是这些支架分层并且表现出快速的完整性丧失。具有和不具有纳米颗粒的猪隔膜支架显示出组织重塑和细胞浸润的迹象，没有包囊的迹象。尽管两种新型支架的性能没有显着差异，但金纳米颗粒支架通常表现出更高的细胞浸润性。这项研究证明了金纳米颗粒组织支架的潜在生物相容性。

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