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首页> 外文期刊>Journal of biomedical materials research, Part A >Silica-based mesoporous nanobiomaterials as promoter of bone regeneration process
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Silica-based mesoporous nanobiomaterials as promoter of bone regeneration process

机译：二氧化硅基介孔纳米生物材料作为骨再生过程的促进剂

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Silica-based mesostructured nanomaterials have emerged as a full family of biomaterials with tremendous potential to address the requirements for the bone regeneration process. This review focuses on more recent advances in bone regeneration process based on silica-based mesoporous biomaterials during 2012 to January 2015. In this review, we describe application of silica-based mesoporous mesostructured nanomaterials (possessing pore sizes in the range 2-50 nm) for the bone regeneration process. We summarize the preparation methods, the effect of mesopore templates and composition on the mesopore-structure characteristics, and different forms of these materials, including particles, fibers, spheres, scaffolds, and composites. The effect of structural and textural properties of mesoporous materials on the development of new biomaterials for treatment of different bone pathologies such as infection, osteoporosis, cancer, and so forth is discussed. In addition, silica-based mesoporous bioactive glass, as a potential drug/growth factor carrier, is reviewed, which includes the composition-structure-drug delivery relationship and the functional effect on the antibacteria and tissue-stimulation properties. Also, application of different mesoporous materials on construction of 3D macroporous scaffolds for bone tissue engineering was disused. Finally, this review discusses the possibility of covalently grafting different osteoinductive agents to the silica-based mesoporous scaffold surface that act as attracting signals for bone cells to promote the bone regeneration process. (c) 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 3703-3716, 2015.
机译：基于二氧化硅的介观结构的纳米材料已经成为一种完整的生物材料家族，具有巨大的潜力来满足骨骼再生过程的要求。这篇综述着重于2012年至2015年1月基于二氧化硅基介孔生物材料的骨再生过程中的最新进展。在这篇综述中，我们描述了基于二氧化硅介孔介孔结构的纳米材料的应用（具有2-50 nm的孔径）用于骨骼再生过程。我们总结了制备方法，中孔模板和组成对中孔结构特征的影响以及这些材料的不同形式，包括颗粒，纤维，球体，支架和复合材料。讨论了介孔材料的结构和质地特性对新型生物材料开发的影响，该新生物材料用于治疗不同的骨病理学，例如感染，骨质疏松，癌症等。另外，综述了作为潜在的药物/生长因子载体的基于二氧化硅的中孔生物活性玻璃，其包括组成-结构-药物递送关系以及对抗菌和组织刺激性质的功能作用。而且，在用于骨组织工程的3D大孔支架的构建中，已不使用不同的介孔材料。最后，本篇文章讨论了将不同的骨诱导剂共价接枝到二氧化硅基介孔支架表面的可能性，该表面充当骨细胞的吸引信号以促进骨再生过程。 （c）2015 Wiley Periodicals，Inc. J Biomed Mater Res Part A：103A：3703-3716，2015年。

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