Novel anti-infection agents: small-molecule inhibitors of bacterial transcription factors.

Bowser TE; Bartlett VJ; Grier MC; Verma AK; Warchol T; Levy SB; Alekshun MN

首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >Novel anti-infection agents: small-molecule inhibitors of bacterial transcription factors.

【24h】

Novel anti-infection agents: small-molecule inhibitors of bacterial transcription factors.

机译：新型抗感染剂：细菌转录因子的小分子抑制剂。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Structure-based drug design was utilized to identify potent small-molecule inhibitors of proteins within the AraC family of bacterial transcription factors, which control virulence in medically important microbes. These agents represent a novel approach to fight infectious disease and may be less likely to promote resistance development. These compounds lack intrinsic antibacterial activity in vitro and were able to limit a bacterial infection in a mouse model of urinary tract infection.

机译：基于结构的药物设计被用于鉴定AraC细菌转录因子家族中有效的小分子蛋白质抑制剂，该抑制剂可控制医学上重要微生物的毒力。这些药物代表了对抗传染病的新方法，可能不太可能促进耐药性的发展。这些化合物在体外缺乏固有的抗菌活性，并且能够在尿路感染的小鼠模型中限制细菌感染。

著录项

来源
《Bioorganic and Medicinal Chemistry Letters》 |2007年第20期|共4页
作者
Bowser TE; Bartlett VJ; Grier MC; Verma AK; Warchol T; Levy SB; Alekshun MN;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;生物化学;
关键词
Molecule; Infection as complication of medical care; inhibitors; Transcription Factors; 转录因子;

机译：Molecule;Infection as complication of medical care;inhibitors;Transcription Factors;转录因子;

相似文献

外文文献
中文文献
专利

1. Novel anti-infection agents: small-molecule inhibitors of bacterial transcription factors. [J] . Bowser TE, Bartlett VJ, Grier MC, Bioorganic and Medicinal Chemistry Letters . 2007,第20期

机译：新型抗感染剂：细菌转录因子的小分子抑制剂。
2. A small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloproteinase-9 expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells. [J] . Chen YJ, Chang WM, Liu YW Chemico-biological interactions . 2009,第3期

机译：一种小分子转移抑制剂降冰片素通过抑制结肠直肠癌细胞Sp1的转录活性来下调基质金属蛋白酶9的表达。
3. A non-bacterial transcription factor inhibits bacterial transcription by a multipronged mechanism [J] . SheppardC., JamesE., BartonG., RNA biology . 2013,第4期

机译：非细菌转录因子通过多重机制抑制细菌转录
4. Identification and quantitation of phosphorylation sites in MEF2 transcription factors. [C] . David M Cox, Nathaniel B Nowacki, Brigitte Simons, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：MEF2转录因子中磷酸化位点的鉴定和定量。
5. The utilization of flavonoids as inhibitors of urease and as antimalarial agents and the discovery of bacterial methionine aminopeptidase inhibitors. [D] . Helgren, Travis Robert. 2016

机译：黄酮类化合物作为脲酶抑制剂和抗疟剂的利用以及细菌蛋氨酸氨基肽酶抑制剂的发现。
6. TATA box-binding protein (TBP) is a constituent of the polymerase I-specific transcription initiation factor TIF-IB (SL1) bound to the rRNA promoter and shows differential sensitivity to TBP-directed reagents in polymerase I II and III transcription factors. [O] . C A Radebaugh, J L Matthews, G K Geiss, 1994

机译：TATA盒结合蛋白（TBP）是与rRNA启动子结合的聚合酶I特异性转录起始因子TIF-IB（SL1）的组成部分在聚合酶III和III转录因子中对TBP定向试剂表现出不同的敏感性。
7. Nusbiarylins, a new class of antimicrobial agents: Rational design of bacterial transcription inhibitors targeting the interaction between the NusB and NusE proteins [O] . Yangyi Qiu, Shu Ting Chan, Lin Lin, 2019

机译：NUSBARYLINS，一类新的抗菌剂：靶向NUSB和NUSUS蛋白之间相互作用的细菌转录抑制剂的合理设计

Novel anti-infection agents: small-molecule inhibitors of bacterial transcription factors.

摘要

著录项

相似文献

相关主题

期刊订阅