...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biomedical materials research, Part A >A novel porous collagen scaffold around an implantable biosensor for improving biocompatibility. I. In vitro/in vivo stability of the scaffold and in vitro sensitivity of the glucose sensor with scaffold.
【24h】

A novel porous collagen scaffold around an implantable biosensor for improving biocompatibility. I. In vitro/in vivo stability of the scaffold and in vitro sensitivity of the glucose sensor with scaffold.

机译：一种可植入生物传感器周围的新型多孔胶原支架，用于改善生物相容性。 I.支架的体外/体内稳定性和具有支架的葡萄糖传感器的体外敏感性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A new 3D porous and biostable collagen scaffold has been developed to improve the biocompatibility of implantable glucose sensors by minimizing tissue reactions while stimulating angiogenesis around the sensors. The novel collagen scaffold was crosslinked using nordihydroguaiaretic acid (NDGA) to enhance biostability. NDGA-treated collagen scaffolds were stable without physical deformation in the subcutaneous tissue of rats for 4 weeks. In contrast, glutaraldehyde (GA)-treated collagen scaffolds were extremely damaged following implantation. Both types of scaffolds (NDGA- and GA-crosslinked) were stable in vitro in the presence of collagenase with 70% retention of original weight after 4 weeks of incubation. The response current (i.e. sensitivity) of sensors with porous scaffolds was not significantly changed when compared with control sensors (no scaffold), while the response time (T(95%)) was slightly delayed after a glucose concentration increase from 5 to 15 mM. Above this range, the sensors coatedwith scaffolds had only a slightly lower sensitivity than the control sensors. These results indicate that we have developed a stable NDGA-crosslinked collagen scaffold for biosensors, and that the scaffold does not impair the function of our sensor. We plan to use this scaffold to enhance the function and lifetime of the implantable biosensors by providing a controlled local environment around the sensors with the help of various drugs and growth factors (dexamethasone, VEGF, PDGF).
机译：已经开发了一种新的3D多孔且生物稳定的胶原蛋白支架，以通过最小化组织反应并同时刺激传感器周围的血管生成来改善可植入葡萄糖传感器的生物相容性。使用去甲二氢愈创木酸（NDGA）将新型胶原蛋白支架交联以增强生物稳定性。 NDGA处理的胶原蛋白支架在大鼠皮下组织中稳定了4周，没有发生物理变形。相比之下，戊二醛（GA）处理的胶原蛋白支架在植入后被严重破坏。孵育4周后，两种类型的支架（NDGA和GA交联的）在体外均稳定，胶原酶存在，原始重量保留70％。与对照传感器（无支架）相比，多孔支架传感器的响应电流（即灵敏度）没有明显变化，而葡萄糖浓度从5 mM增加到15 mM后响应时间（T（95％））略有延迟。高于此范围，涂有支架的传感器的灵敏度仅比控制传感器低一点。这些结果表明我们已经开发了用于生物传感器的稳定的NDGA交联胶原蛋白支架，并且该支架不会损害我们传感器的功能。我们计划通过在各种药物和生长因子（地塞米松，VEGF，PDGF）的帮助下在传感器周围提供可控的局部环境，来使用这种支架来增强可植入生物传感器的功能和寿命。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号