...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Rapid prototyped sutureless anastomosis device from self-curing silk bio-ink
【24h】

Rapid prototyped sutureless anastomosis device from self-curing silk bio-ink

机译：利用自固化丝绸生物墨水快速原型化无缝合吻合装置

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Sutureless anastomosis devices are designed to reduce surgical time and difficulty, which may lead to quicker and less invasive cardiovascular anastomosis. The implant uses a barb-and-seat compression fitting composed of one male and two female components. The implant body is resorbable and capable of eluting heparin. Custom robotic deposition equipment was designed to fabricate the implants from a self-curing silk solution. Curing did not require deleterious processing steps but devices demonstrated high crush resistance, retention strength, and leak resistance. Radial crush resistance is in the range of metal vascular implants. Insertion force and retention strength of the anastomosis was dependent on fit sizing of the male and female components and subsequent vessel wall compression. Anastomotic burst strength was dependent on the amount of vessel wall compression, and capable of maintaining higher than physiological pressures. In initial screening using a porcine implant, the devices remained intact for 28 days (the length of study). Histological sections revealed cellular infiltration within the laminar structure of the male component, as well as at the interface between the male and female components. Initial degradation and absorption of the implant wall were observed. The speed per anastomosis using this new device was much faster than current systems, providing significant clinical improvement. (C) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 1333-1343, 2015.
机译：无缝合吻合装置旨在减少手术时间和难度，这可能会导致更快和更少侵入性的心血管吻合。植入物使用由一个凸形和两个凹形组成的倒钩和座椅压缩配件。植入物主体是可吸收的，能够洗脱肝素。定制的自动沉积设备被设计为使用自固化的丝溶液制造植入物。固化不需要有害的加工步骤，但是器件显示出高的抗压碎性，保持强度和抗渗漏性。径向抗压性在金属血管植入物的范围内。吻合的插入力和保持强度取决于公母组件的合适尺寸以及随后的血管壁压缩。吻合口破裂强度取决于血管壁受压的程度，并且能够维持高于生理压力。在使用猪植入物的初步筛选中，设备保持完整28天（研究时间）。组织学切片显示在雄性组件的层状结构内以及雄性和雌性组件之间的界面内有细胞浸润。观察到植入物壁的最初降解和吸收。使用这种新设备的每次吻合术的速度比现有系统快得多，可提供显着的临床改善。 （C）2014 Wiley Periodicals，Inc. J Biomed Mater Res B部分：Appl Biomater，103B：1333-1343，2015。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号