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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Comparison of sequential drug release in vitro and in vivo
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Comparison of sequential drug release in vitro and in vivo

机译：体内和体外顺序药物释放的比较

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Development of drug-delivery devices typically involves characterizing in vitro release performance with the inherent assumption that this will closely approximate in vivo performance. Yet, as delivery devices become more complex, for instance with a sequential drug release pattern, it is important to confirm that in vivo properties correlate with the expected programming achieved in vitro. In this work, a systematic comparison between in vitro and in vivo biomaterial erosion and sequential release was performed for a multilayered association polymer system comprising cellulose acetate phthalate and Pluronic F-127. After assessing the materials during incubation in phosphate-buffered saline, devices were implanted supracalvarially in rats. Devices with two different doses and with different erosion rates were harvested at increasing times post-implantation, and the in vivo thickness loss, mass loss, and the drug release profiles were compared with their in vitro counterparts. The sequential release of four different drugs observed in vitro was successfully translated to in vivo conditions. Results suggest, however, that the total erosion time of the devices was longer and that release rates of the four drugs were different, with drugs initially released more quickly and then more slowly in vivo. Many comparative studies of in vitro and in vivo drug release from biodegradable polymers involved a single drug, whereas this research demonstrated that sequential release of four drugs can be maintained following implantation. (c) 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1302-1310, 2016.
机译：药物递送装置的开发通常涉及表征体外释放性能，其固有假设是，这将非常接近于体内性能。然而，随着递送装置变得更加复杂，例如具有连续的药物释放模式，重要的是要确认体内特性与体外实现的预期程序相关。在这项工作中，对包含醋酸邻苯二甲酸纤维素和Pluronic F-127的多层缔合聚合物系统进行了体外和体内生物材料侵蚀和顺序释放之间的系统比较。在磷酸盐缓冲液中温育期间评估材料后，将装置经颅上植入大鼠中。在植入后增加时间收获具有两种不同剂量和不同腐蚀速率的器械，并将其体内厚度损失，质量损失和药物释放曲线与其体外对照进行比较。在体外观察到的四种不同药物的顺序释放已成功转化为体内条件。然而，结果表明，装置的总腐蚀时间更长，并且四种药物的释放速率不同，药物在体内最初释放得更快，然后释放得更慢。从可生物降解的聚合物进行体外和体内药物释放的许多比较研究都涉及一种药物，而这项研究表明，植入后可以维持四种药物的顺序释放。 （c）2015 Wiley Periodicals，Inc. J Biomed Mater Res B部分：Appl Biomater，104B：1302-1310，2016。

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