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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Effect of hydroxyapatite content on physical properties and connective tissue reactions to a chitosan-hydroxyapatite composite membrane.
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Effect of hydroxyapatite content on physical properties and connective tissue reactions to a chitosan-hydroxyapatite composite membrane.

机译：羟基磷灰石含量对壳聚糖-羟基磷灰石复合膜物理性能和结缔组织反应的影响。

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摘要

The present study investigated the effect on certain physical properties of adding various amounts of hydroxyapatite (HAP) to chitosan sol. Also investigated were connective tissue reactions to a composite membrane that is being developed for possible use in guided tissue regeneration and for the limitation of HA particle migration at sites of implantation. The physical properties evaluated were shrinkage, tensile strength, hardness, calcium ion release, and morphology. Assessment of physical properties indicated that a ratio of HA to chitosan sol of 4/11 by weight is optimal in the preparation of the composite membrane. Subperiosteal implantation of the membranes over rat calvaria revealed that the membranes were well tolerated, with fibrous encapsulation and occasional areas of osteogenesis. Increasing the hydroxyapatite content seems to enhance membrane degradation. Copyright 1999 John Wiley & Sons, Inc.
机译：本研究调查了在壳聚糖溶胶中添加各种量的羟基磷灰石（HAP）对某些物理性能的影响。还研究了与复合膜的结缔组织反应，该复合膜正在开发中，可用于引导组织再生并限制HA粒子在植入部位的迁移。评价的物理性能为收缩率，抗张强度，硬度，钙离子释放和形态。物理性质的评估表明，在复合膜的制备中，HA与壳聚糖溶胶的重量比为4/11是最佳的。骨膜下在大鼠颅骨上的骨膜下植入表明，该膜具有良好的耐受性，具有纤维包囊和偶发的成骨区域。羟磷灰石含量的增加似乎促进了膜的降解。版权所有1999 John Wiley＆Sons，Inc.

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