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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Ricinoleic acid-based biopolymers.
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Ricinoleic acid-based biopolymers.

机译：基于蓖麻油酸的生物聚合物。

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摘要

Polyanhydrides synthesized from pure ricinoleic acid half-esters with maleic and succinic anhydrides possess desired physicochemical and mechanical properties for use as drug carriers. Ricinoleic acid maleate or succinate diacid half-esters were prepared from the reaction of crude ricinoleic acid (85% content) with succinic or maleic anhydride. The pure diacid monomers were obtained by chromatography purification through silica gel using petroleum ether/ethyl acetate/acetic acid (80/30/1 v/v/v) mixture as eluent. The pure diacid monomers (>99%) were polymerized by melt condensation to yield film-forming polymers with molecular weights exceeding 40,000 with a polydispersity of 2. Extensive biocompatibility study demonstrated their toxicological inertness and biodegradability. Their rate of elimination from rats in the course of about 4-6 weeks was faster than that found for similar fatty acid-based polyanhydrides previously tested. In vitro studies showed that these polymers underwent rapid hydrolytic degradation in 10 days. Methotrexate release from the polymers was not affected by the initial polymer molecular weight in the range of 10,000-35,000. The in vitro drug release correlated with the degradation of the polymers. The fatty acid ester monomers were further degraded to its counterparts, ricinoleic acid and succinic or maleic acid. Copyright 1999 John Wiley & Sons, Inc.
机译：由纯蓖麻油酸半酯与马来酸酐和琥珀酸酐合成的聚酸酐具有用作药物载体的所需理化和机械性能。由粗蓖麻油酸（含量为85％）与琥珀酸或马来酸酐反应制备蓖麻油酸马来酸酯或琥珀酸二酸半酯。通过使用石油醚/乙酸乙酯/乙酸（80/30/1 v / v / v）混合物作为洗脱剂的硅胶色谱纯化法获得纯的二酸单体。通过熔融缩合将纯二酸单体（> 99％）聚合，得到分子量超过40,000的成膜聚合物，多分散度为2。广泛的生物相容性研究表明，它们具有毒理学惰性和可生物降解性。在大约4-6周的过程中，它们从大鼠中清除的速度比以前测试过的类似的基于脂肪酸的聚酐所发现的速度更快。体外研究表明，这些聚合物在10天内迅速水解降解。从聚合物释放甲氨蝶呤不受初始聚合物分子量在10,000-35,000之间的影响。体外药物释放与聚合物的降解有关。脂肪酸酯单体进一步降解为其对应物蓖麻油酸和琥珀酸或马来酸。版权所有1999 John Wiley＆Sons，Inc.

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