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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Fibrous tissue ingrowth and attachment to porous tantalum
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Fibrous tissue ingrowth and attachment to porous tantalum

机译：纤维组织向内生长并附着在多孔钽上

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摘要

This study determined the soft tissue attachment and extent of ingrowth to a porous tantalum biomaterial. Eight dorsal subcutaneous implants (in two dogs) were evaluated at 4, 8, and 16 weeks. Upon retrieval, all implants were surrounded completely by adherent soft tissue. Implants were harvested with a tissue flap on the cutaneous aspect and peel tested in a servo-hydraulic tensile test machine at a rate of 5 mm/mm. Following testing, implants were dehydrated in a solution of basic fuschin, defatted, embedded in methylmethacrylate, and processed for thin-section histology. At 4, 8, and 16 weeks, the attachment strength to porous tantalum was 61, 71, and 89 g/mm respectively. Histologic analysis showed complete tissue ingrowth throughout the porous tantalum implant. Blood vessels were visible at the interface of and within the porous tantalum material. Tissue maturity and vascularity increased with time. The tissue attachment strength to porous tantalum was three- to six-fold greater than was reported in a similar study with porous beads. This study demonstrated that porous tantalum permits rapid ingrowth of vascularized soft tissue, and attains soft tissue attachment strengths greater than with porous beads.
机译：这项研究确定了软组织对多孔钽生物材料的附着和向内生长的程度。在第4、8和16周评估了八只背侧皮下植入物（两只狗）。取出后，所有植入物都被粘附的软组织完全包围。在皮肤方面用组织瓣收获植入物，并在伺服液压拉伸试验机中以5mm / mm的速率进行剥离测试。经过测试后，将植入物在碱性表扣的溶液中脱水，脱脂，包埋在甲基丙烯酸甲酯中，并进行薄切片组织学处理。在第4、8和16周时，与多孔钽的附着强度分别为61、71和89 g / mm。组织学分析显示整个多孔钽植入物中组织完全向内生长。在多孔钽材料的界面处和内部可见血管。组织成熟度和血管随着时间增加。组织对多孔钽的附着强度比多孔珠类似研究中报道的强度高三到六倍。这项研究表明，多孔钽可使带血管的软组织快速向内生长，并获得比多孔珠更大的软组织附着强度。

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