...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Controllable dual-release of dexamethasone and bovine serum albumin from PLGA/beta-tricalcium phosphate composite scaffolds.
【24h】

Controllable dual-release of dexamethasone and bovine serum albumin from PLGA/beta-tricalcium phosphate composite scaffolds.

机译：从PLGA /β-磷酸三钙复合材料支架中地塞米松和牛血清白蛋白的可控双重释放。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Localized dual-drug delivery from biodegradable scaffolds is an important strategy in tissue engineering. In this study, porous poly(L-lactide-co-glycolide) (PLGA)/beta-tricalcium phosphate scaffolds containing both dexamethasone (Dex) and bovine serum albumin (BSA) were prepared by incorporating Dex-loaded and BSA-loaded microspheres into the scaffolds. PLGA microspheres containing Dex or BSA were prepared by spray-drying and double emulsion/solvent evaporation, respectively. In vitro release studies indicated that microspheres prepared from PLGA in 3:1 molar ratio of L-lactide/glycolide and 89.5 kDa relative molecular mass showed prolonged release profiles compared with those prepared from PLGA in 1:1 L-lactide/glycolide molar ratio and 30.5 kDa relative molecular mass. Additionally, introduction of poly(ethylene glycol) in the PLGA chain could improve the encapsulation efficiency and reduce the release rate. Based on the above results, controllable dual-release of Dex and BSA with relatively higher or lower release rate was achieved by incorporating Dex-loaded and BSA-loaded microspheres with different release profiles into the PLGA/beta-tricalcium phosphate scaffolds.
机译：从生物可降解支架的局部双重药物输送是组织工程中的重要策略。在这项研究中，通过将Dex负载和BSA负载的微球体掺入含有地塞米松（Dex）和牛血清白蛋白（BSA）的多孔聚（L-丙交酯-共-乙交酯）（PLGA）/β-三钙磷酸钙支架中，脚手架。含有Dex或BSA的PLGA微球分别通过喷雾干燥和双重乳液/溶剂蒸发法制备。体外释放研究表明，与由PLGA制备的L-丙交酯/乙交酯摩尔比为3：1和相对分子质量为89.5 kDa的微球相比，PLGA制备的微球具有更长的释放曲线。相对分子质量为30.5 kDa。另外，在PLGA链中引入聚乙二醇可以提高包封效率并降低释放速率。基于以上结果，通过将具有不同释放曲线的Dex负载和BSA负载微球掺入PLGA /β-磷酸三钙支架中，实现了具有相对较高或较低释放速率的Dex和BSA的可控双重释放。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号