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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Synergistlc effect of resveratrol and quercetin released from drug-eluting polymer coatings for endovascular devices
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Synergistlc effect of resveratrol and quercetin released from drug-eluting polymer coatings for endovascular devices

机译：从用于血管内装置的药物洗脱聚合物涂层中释放的白藜芦醇和槲皮素的协同作用

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This study describes the development and evaluation of novel polymer films that provide.controlled release of two vascular-protective polyphenols for endovascular devices. Resveratrol (RESV) and quercetin (QUER) have antimi-gratory and antiproliferative actions on vascular smooth muscle cells (VSMCs), inhibit both platelet and inflammatory cell activation, and promote endothelial cell function. Our aim is to develop and characterize coatings that release these drugs within a therapeutic range. The most synergistic drug combination, as determined by isobolographic analysis, was incorporated into an arborescent poly(styrene-isobutylene-styrene) tri-block polymer (ariblBS) and applied to stainless steel coupons using an electrospray process. Physical characterization of the resulting coating revealed a film featuring micro-scale architecture consisting of drug-containing domains. To determine drug-mediated effects, vascular cells were exposed to coatings incorporating several loadings of RESV and QUER. Results from this study indicate that arblBS exhibits no cytotoxicity, and that the films release RESV and QUER at therapeutic levels, dose-dependently inhibiting mac-rophage activation, VSMC proliferation, and platelet stimulation. We conclude that RESV and QUER released from anblBS interfere with key processes responsible for in-stent stenosis, suggesting that RESV and QUER may have utility as therapeutics in a novel coating for device-based interventions.
机译：这项研究描述了新型聚合物薄膜的开发和评估，该薄膜可控制释放两种用于血管内装置的血管保护性多酚。白藜芦醇（RESV）和槲皮素（QUER）对血管平滑肌细胞（VSMC）具有抗迁移和抗增殖作用，抑制血小板和炎性细胞活化，并促进内皮细胞功能。我们的目标是开发和表征可在治疗范围内释放这些药物的涂层。通过等效线照相法分析确定的最具协同作用的药物组合被掺入树状聚（苯乙烯-异丁烯-苯乙烯）三嵌段聚合物（ariblBS）中，并使用电喷雾工艺应用于不锈钢试样。所得涂层的物理表征揭示了一种薄膜，该薄膜具有包含药物域的微观结构。为了确定药物介导的作用，将血管细胞暴露于掺有几种RESV和QUER的涂层中。这项研究的结果表明，arblBS没有表现出细胞毒性，并且该膜以治疗水平释放RESV和QUER，剂量依赖性地抑制了巨噬细胞活化，VSMC增殖和血小板刺激。我们得出的结论是，从anblBS释放出来的RESV和QUER会干扰负责支架内狭窄的关键过程，这表明RESV和QUER可能在基于设备的干预的新型涂层中用作治疗剂。

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