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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Improved bio-implant using ultrafast laser induced self-assembled nanotexture in titanium.
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Improved bio-implant using ultrafast laser induced self-assembled nanotexture in titanium.

机译：使用钛中超快激光诱导的自组装纳米纹理改进了生物植入物。

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摘要

The most successful metal implant materials currently have relatively smooth surfaces on the micron size scale, with most failures occurring after only 10 years. To move beyond this limiting time scale, texturing methods have been developed to modify the metal surface to enhance integration of the implant directly with surrounding bone. A flexible single-step ultrafast-laser texturing process has been developed that results in a surface texture that exhibits micron scale peaks and troughs with superimposed submicron and nano-scale features. The textured titanium samples remain completely hydrophilic with no measurable contact angle even after several weeks in normal atmosphere. An increase in mesenchymal stem cell number is observed over that on an untreated control titanium surface. Extensive formation of cellular bridges by stromal cells between pillars shows the favorable response of differentiated cells to the surface and the promotion of their attachment. Expression of the alkaline phosphatase and osteocalcin genes in human bone marrow cells were seen to increase on the textured surface. The development of this single-step method for creating micron, submicron, and nano-scale surface texture directly on metals makes a significant contribution to the goal of improving the integration and life span of joint replacement implants.
机译：目前，最成功的金属植入物材料的表面具有微米级的相对光滑的表面，大多数失败仅在10年后发生。为了超越此限制的时间尺度，已经开发出纹理化方法来修饰金属表面，以增强植入物与周围骨骼的直接整合。已经开发了一种灵活的单步超快激光纹理化工艺，该工艺可产生具有微米级峰和谷的表面纹理，并具有叠加的亚微米和纳米级特征。织构化的钛样品即使在正常大气中几周后仍保持完全亲水性，没有可测量的接触角。与未经处理的对照钛表面相比，间充质干细胞数量增加。柱之间的基质细胞广泛形成细胞桥，表明分化的细胞对表面的良好反应及其附着的促进。可见在人的骨髓细胞中碱性磷酸酶和骨钙素基因的表达在有纹理的表面上增加。这种直接在金属上创建微米，亚微米和纳米级表面纹理的单步方法的发展，对改善关节置换植入物的集成度和使用寿命的目标做出了重大贡献。

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