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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Study of the mechanism of insulin encapsulation in poly(isobutylcyanoacrylate) nanocapsules obtained by interfacial polymerization.
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Study of the mechanism of insulin encapsulation in poly(isobutylcyanoacrylate) nanocapsules obtained by interfacial polymerization.

机译：界面聚合得到的聚（氰基丙烯酸异丁酯）纳米胶囊中胰岛素包封机理的研究。

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In previous studies, insulin-loaded poly(alkylcyanoacrylate) nanocapsules were found to reduce the blood glucose level after oral administration to diabetic rats and dogs. The reduction of the glycemia induced by the nanocapsules was the same regardless of the insulin doses administered, but the effect appeared only after a delay of a few days. The purpose of this study was to investigate the mechanism of insulin encapsulation and the type of interactions that may exist between the polymer forming the nanocapsule wall and the insulin. The results of this study showed, based on the interfacial polymerization of isobutylcyanoacrylate, that the insulin molecule is not chemically modified during the nanoencapsulation process. In addition, no interaction between the poly(isobutylcyanoacrylate) and the insulin could be observed. The observed high encapsulation efficiency of intact insulin may be explained by the fact that the ethanol used in the preparation of the nanocapsules is responsible for the initiation of the interfacial polymerization of isobutylcyanoacrylate instead of the insulin. The zeta potential measurements suggest that insulin is located within the core of the nanocapsules. Thus the biological activity of the nanoencapsulated peptide and the high efficiency of insulin encapsulation achieved with this nanoencapsulation process cannot be explained by a specific interaction of the insulin with the polymer forming the nanocapsule's wall. It may be due, however, to the fact that the encapsulated insulin molecule is chemically intact and located within the oily core of the nanocapsules. Copyright 1999 John Wiley & Sons, Inc.
机译：在以前的研究中，发现对糖尿病大鼠和狗口服给药后，载有胰岛素的聚（氰基丙烯酸烷基酯）纳米胶囊可降低血糖水平。不管施用的胰岛素剂量如何，由纳米胶囊诱导的血糖降低的减少是相同的，但是这种效果仅在延迟几天后才出现。这项研究的目的是研究胰岛素包封的机制以及形成纳米囊壁的聚合物与胰岛素之间可能存在的相互作用类型。这项研究的结果表明，基于异氰酸氰基异丁酯的界面聚合，在纳米囊化过程中胰岛素分子没有化学修饰。另外，未观察到聚（氰基丙烯酸异丁酯）与胰岛素之间的相互作用。观察到的完整胰岛素的高包封效率可以由以下事实解释：用于制备纳米胶囊的乙醇负责引发异氰酸氰基丙烯酸异丁酯而不是胰岛素的界面聚合。 Zeta电位测量表明胰岛素位于纳米胶囊的核心内。因此，不能通过胰岛素与形成纳米胶囊壁的聚合物的特异性相互作用来解释纳米胶囊化肽的生物活性和通过该纳米胶囊化过程实现的胰岛素胶囊化的高效率。然而，这可能是由于包封的胰岛素分子是化学完整的并且位于纳米胶囊的油性核内的事实。版权所有1999 John Wiley＆Sons，Inc.

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