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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Effects of metal ions on white blood cells of patients with failed total joint arthroplasties.
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Effects of metal ions on white blood cells of patients with failed total joint arthroplasties.

机译：金属离子对全关节置换失败患者白细胞的影响。

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In this study twenty-two patients who had revision surgery for aseptic loosening of joint prostheses were examined. The concentration in serum of soluble products of corrosion from the implant, that is, chromium (Cr), cobalt (Co), and nickel (Ni) ions, and the number of white blood cells (leucocytes, myeloid cells, lymphocyte subpopulations) were measured. Twenty patients with no implants were used as controls. The patients who had revision surgery showed normal Ni concentration whereas by statistical analysis that same patient group was shown to have serum Cr and Co levels significantly higher than those of the control. By flow cytometry, a significant decrease of leucocytes, myeloid cells, lymphocytes, and CD16 populations as found in patients versus controls whereas CD3, CD4, CD8, and CD20 positive cells were decreased, but not significantly. In the arthroplasty patients the Cr concentrations were inversely correlated with some of the immunologic parameters while no significant correlation was found between Co levels and decreased lymphocyte subpopulations. Only in revision surgery patients with high Cr concentrations did we find a significant decrease of lymphocytes, namely of CD4 and CD16 positive cells; revision surgery patients with normal Cr concentrations did not show a significant decrease of lymphocyte subpopulations. These data suggest that the presence of metal ions, especially chromium, released from prosthesis components could be associated with changes of lymphocyte subpopulations in patients with loosening of joint prostheses. Copyright 1999 John Wiley & Sons, Inc.
机译：在这项研究中，检查了22例因关节假体无菌性松动而接受翻修手术的患者。植入物产生的腐蚀的可溶性产物（即铬（Cr），钴（Co）和镍（Ni）离子）在血清中的浓度以及白细胞（白细胞，髓样细胞，淋巴细胞亚群）的数量为测量。 20例无植入物的患者用作对照。接受翻修手术的患者显示正常的镍浓度，而通过统计分析表明，同一患者组的血清铬和钴水平明显高于对照组。通过流式细胞仪，与对照组相比，患者中白细胞，髓样细胞，淋巴细胞和CD16群体显着减少，而CD3，CD4，CD8和CD20阳性细胞则减少，但没有显着降低。在关节置换患者中，Cr浓度与某些免疫学参数呈负相关，而Co水平与淋巴细胞亚群减少之间则无显着相关性。只有在高Cr浓度的翻修手术患者中，我们才发现淋巴细胞显着减少，即CD4和CD16阳性细胞。 Cr浓度正常的翻修手术患者的淋巴细胞亚群没有明显减少。这些数据表明，在假体松动的患者中，假体组分释放出的金属离子，尤其是铬，可能与淋巴细胞亚群的变化有关。版权所有1999 John Wiley＆Sons，Inc.

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