...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Synthesis and characterization of polypyrrole-hyaluronic acid composite biomaterials for tissue engineering applications.
【24h】

Synthesis and characterization of polypyrrole-hyaluronic acid composite biomaterials for tissue engineering applications.

机译：用于组织工程应用的聚吡咯-透明质酸复合生物材料的合成与表征。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

New tissue engineering technologies will rely on biomaterials that physically support tissue growth and stimulate specific cell functions. The goal of this study was to create a biomaterial that combines inherent biological properties which can specifically trigger desired cellular responses (e.g., angiogenesis) with electrical properties which have been shown to improve the regeneration of several tissues including bone and nerve. To this end, composites of the biologically active polysaccharide hyaluronic acid (HA) and the electrically conducting polymer polypyrrole (PP) were synthesized and characterized. Electrical conductivity of the composite biomaterial (PP/HA) was measured by a four-point probe technique, scanning electron microscopy was used to characterize surface topography, X-ray photoelectron spectroscopy and reflectance infrared spectroscopy were used to evaluate surface and bulk chemistry, and an assay with biotinylated hyaluronic acid binding protein was used to determine surface HA content. PP/HA materials were also evaluated for in vitro cell compatibility and tissue response in rats. Smooth, conductive, HA-containing PP films were produced; these films retained HA on their surfaces for several days in vitro and promoted vascularization in vivo. PP/HA composite biomaterials are promising candidates for tissue engineering and wound-healing applications that may benefit from both electrical stimulation and enhanced vascularization. Copyright 2000 John Wiley & Sons, Inc.
机译：新的组织工程技术将依靠物理上支持组织生长并刺激特定细胞功能的生物材料。这项研究的目的是创建一种生物材料，该材料结合了可以固有地触发所需细胞反应（例如血管生成）的固有生物学特性和已被证明可以改善包括骨骼和神经在内的多种组织再生的电学特性。为此，合成并表征了生物活性多糖透明质酸（HA）和导电聚合物聚吡咯（PP）的复合材料。通过四点探针技术测量复合生物材料（PP / HA）的电导率，使用扫描电子显微镜表征表面形貌，使用X射线光电子能谱和反射红外光谱来评估表面和本体化学，以及使用具有生物素化的透明质酸结合蛋白的测定法来测定表面HA的含量。还评估了PP / HA材料在大鼠中的体外细胞相容性和组织反应。生产出光滑，导电，含HA的PP膜;这些薄膜在体外将HA保留在其表面上数天，并在体内促进血管形成。 PP / HA复合生物材料是组织工程和伤口愈合应用的有前途的候选者，可从电刺激和增强的血管形成中受益。版权所有2000 John Wiley＆Sons，Inc.

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号