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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Preservation of platelet function on 2-methacryloyloxyethyl phosphorylcholine-graft polymer as compared to various water-soluble graft polymers
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Preservation of platelet function on 2-methacryloyloxyethyl phosphorylcholine-graft polymer as compared to various water-soluble graft polymers

机译：与各种水溶性接枝聚合物相比，保留了2-甲基丙烯酰氧基乙基磷酰胆碱接枝聚合物的血小板功能

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The chemical structures of water-soluble polymers grafted onto PE surfaces affect platelet function when the platelets contact the polymer surfaces. To improve our understanding of this effect, this study sought to control the blood/materials interaction on the surfaces of polyethylene (PE) by grafting with various water-soluble polymers. Such polymers as poly(2-methacryloyloxyethyl phosphoryicholine) (PMPC), poly(acrylamide) (PAAm), poly(N-vinylpyrrolidone) (PVPy), and poly(monomethacryloyl poly(ethylene glycol)) (PMPEG) were grafted on low-density PE sheets by photoinduced graft polymerization. Both the PE bags modified with water-soluble polymers and those nonmodified were prepared by heat processing. Activation of platelets after storage in the PE bags was evaluated by measuring the cytoplasmic free calcium ion concentration ((Ca~(2+))i). The concentration of (Ca~(2+))i of platelets in contact with the PE surface grafted with PMPC was the same as that of native platelets and significantly less than that in contact with other PE surfaces grafted with water-soluble polymers. The number of adherent platelets was effectively decreased on PE surfaces grafted with PMPC and PMPEG, as compared with nontreated PE. The aggregation ability of platelets was also measured after storage of platelet-rich plasma in the PE bags. The PE surface grafted with PMPC effectively maintained aggregation ability as compared with both the nontreated PE and with PE grafted with PAAm, PVPy, and PMPEC. It was concluded that for preserving platelet function, PMPC was the most effective of these water-soluble polymers used for surface modification.
机译：当血小板接触聚合物表面时，接枝到PE表面的水溶性聚合物的化学结构会影响血小板功能。为了增进我们对这种作用的理解，本研究试图通过接枝各种水溶性聚合物来控制聚乙烯（PE）表面上血液/物质的相互作用。在低-光致接枝聚合制备高密度PE片材。用水溶性聚合物改性的PE袋和未改性的PE袋都是通过热处理制备的。通过测量细胞质中游离钙离子浓度（（Ca〜（2 +））i）评估PE袋中储存后的血小板活化。与接枝有PMPC的PE表面接触的血小板的（Ca〜（2 +））i浓度与天然血小板相同，并且显着小于与接枝有水溶性聚合物的其他PE表面接触的血小板的浓度。与未处理的PE相比，在用PMPC和PMPEG移植的PE表面有效减少了粘附血小板的数量。在将富含血小板的血浆保存在PE袋中后，还测量了血小板的聚集能力。与未处理的PE和PAAm，PVPy和PMPEC接枝的PE相比，PMPC接枝的PE表面有效地保持了聚集能力。结论是为了保持血小板功能，PMPC是这些用于表面修饰的水溶性聚合物中最有效的。

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