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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >An evaluation of BMP-2 delivery from scaffolds with miniaturized dental implants in a novel rat mandible model.
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An evaluation of BMP-2 delivery from scaffolds with miniaturized dental implants in a novel rat mandible model.

机译：在新型大鼠下颌骨模型中，从具有微型牙科植入物的支架中评估BMP-2的递送。

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摘要

The purpose of this study was three-fold: (a) to develop a new small animal model to evaluate dental implant systems that recapitulates aspects of the challenging intraoral environment, (b) screen several scaffolds for in vivo bone forming efficacy when used to deliver non-glycosylated bone morphogenetic protein-2 (BMP-2) together with a miniaturized titanium (Ti) dental implant, and (c) identify correlations between in vitro BMP-2 release rates and in vivo results. The scaffolds tested were: (1) collagen-hydroxyapatite composite (Col/HA), (2) polyethylene glycol hydrogel (PEG-hydrogel), and (3) Col/HA infused with PEG-hydrogel (Col/HA/PEG-hydrogel). BMP-2 delivery directly from the Ti implants rather than from the scaffolds was also tested. MicroCT analyses at 4 weeks showed that the maximum volume and height of new bone occurred when BMP-2 (10 mug) was delivered from the Col/HA/PEG-hydrogel scaffolds. BMP-2 delivery from the Ti implant was not as effective as from the scaffolds. While in vitro BMP-2 release was highest for the PEG-hydrogel, the scaffold most successful in vivo was the Col/HA/PEG-hydrogel scaffold because it had the necessary mechanical strength to perform well in the mandibular bone environment. The in vitro release studies suggested a threshold dose of 5 mug which was borne out by the in vivo dose response studies.
机译：这项研究的目的是三方面的：（a）开发一种新的小型动物模型来评估可概括口腔内挑战性环境的牙科植入物系统;（b）筛选几种支架以用于体内递送时的体内骨形成功效非糖基化的骨形态发生蛋白2（BMP-2）以及小型化的钛（Ti）牙科植入物，以及（c）确定体外BMP-2释放速率与体内结果之间的相关性。测试的支架为：（1）胶原-羟基磷灰石复合材料（Col / HA），（2）聚乙二醇水凝胶（PEG-水凝胶）和（3）注入PEG-水凝胶（Col / HA / PEG-水凝胶）的Col / HA ）。还测试了直接从Ti植入物而不是从支架植入BMP-2的情况。 4周时的MicroCT分析显示，当从Col / HA / PEG-水凝胶支架中递送BMP-2（10杯）时，出现了新骨的最大体积和最大高度。 Ti植入物的BMP-2递送不如支架有效。 PEG水凝胶的体外BMP-2释放最高，而体内最成功的支架是Col / HA / PEG水凝胶支架，因为它具有在下颌骨环境中良好表现所需的机械强度。体外释放研究表明阈值剂量为5马克，这已通过体内剂量反应研究证实。

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