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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Preparation of a novel anorganic bovine bone xenograft with enhanced bioactivity and osteoconductivity
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Preparation of a novel anorganic bovine bone xenograft with enhanced bioactivity and osteoconductivity

机译：具有增强的生物活性和骨传导性的新型无机牛骨异种移植物的制备

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摘要

A novel anorganic bovine bone xenograft with enhanced bioactivity and osteoconductivity was prepared by an ion substitution method using sodium hypochlorite. Bovine bone granules were defatted, washed, and then soaked in sodium hypochlorite solution at room temperature. Subsequently, the granules were dried and then heat-treated at 1000°C with sodium hypochlorite. As a control, bovine bone granules were prepared with the same conditions but without sodium hypochlorite treatment. Phase, functional group, and elemental analyses by XRD, FTIR, and EPMA showed that the granules heat-treated without and with sodium hypochlorite were pure hydroxyapatite and sodium-chlorine-bearing hydroxyapatite, respectively. After soaking in simulated body fluid (SBF) for 1 week, low crystalline hydroxyl carbonate apatite fully covered the surface of sodium-chlorine-bearing hydroxyapatite, whereas it formed little on the hydroxyapatite surface. After soaking in SBF and deionized water, ICP-AES and IC analyses showed that the dissolutions of calcium, sodium, chlorine, and hydroxyl ions from sodium-chlorine-bearing hydroxyapatite notably increased compared with those from hydroxyapatite. This resultantly increased the ionic activity product of apatite in SBF and induced new formation of low crystalline hydroxyl carbonate apatite. The cytotoxicity test by BCA assay showed that there were no statistically significant differences between hydroxyapatite and sodium-chlorine-bearing hydroxyapatite. In addition, sodium-chlorine-bearing hydroxyapatite showed better osteoconductivity in the calvarial defects of New Zealand white rabbits within 4 weeks compared with that of hydroxyapatite. The results suggest that this novel anorganic bovine bone xenograft possesses encouraging potential for use as a bone grafting material due to better bioactivity and osteoconductivity than hydroxyapatite.
机译：采用次氯酸钠通过离子取代法制备了具有增强的生物活性和骨传导性的新型无机牛异种骨。将牛骨颗粒脱脂，洗涤，然后在室温下浸泡在次氯酸钠溶液中。随后，将颗粒干燥，然后用次氯酸钠在1000℃下热处理。作为对照，在相同条件下但未用次氯酸钠处理制备牛骨颗粒。通过XRD，FTIR和EPMA进行的相，官能团和元素分析表明，未加次氯酸钠和经次氯酸钠热处理的颗粒分别为纯羟基磷灰石和含氯钠的羟基磷灰石。在模拟体液（SBF）中浸泡1周后，低结晶度的碳酸羟基磷灰石完全覆盖了含氯钠的羟基磷灰石表面，而在羟基磷灰石表面几乎没有形成。浸入SBF和去离子水中后，ICP-AES和IC分析表明，与含钠氯的羟基磷灰石相比，含钠氯的羟基磷灰石中钙，钠，氯和羟基离子的溶解度显着增加。结果增加了SBF中磷灰石的离子活性产物，并诱导了低结晶性碳酸羟基磷灰石的新形成。通过BCA分析的细胞毒性测试表明，羟基磷灰石和含氯钠的羟基磷灰石之间没有统计学上的显着差异。此外，与氯磷灰石相比，含氯的羟磷灰石在4周内对新西兰白兔的颅骨缺损显示出更好的骨传导性。结果表明，这种新型的无机牛骨异种移植物具有比羟基磷灰石更好的生物活性和骨传导性，具有令人鼓舞的潜力，可以用作骨移植材料。

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