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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Crosslinking and modification of dermal sheep collagen using 1, 4-butanediol diglycidyl ether.
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Crosslinking and modification of dermal sheep collagen using 1, 4-butanediol diglycidyl ether.

机译：使用1，4-丁二醇二缩水甘油醚对真皮绵羊胶原蛋白进行交联和修饰。

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Crosslinking of dermal sheep collagen (DSC) was accomplished using 1, 4-butanediol diglycidyl ether (BDDGE). At pH values > 8.0, epoxide groups of BDDGE will react with amine groups of collagen. The effects of BDDGE concentration, pH, time, and temperature were studied. Utilization of a 4-wt % BDDGE instead of 1-wt % resulted in a faster reaction. Whereas similar values of shrinkage temperature were obtained, fewer primary amine groups had reacted at a lower BDDGE concentration, which implies that the crosslinking reaction had a higher efficacy. An increase in pH from 8.5 to 10.5 resulted in a faster reaction but reduced crosslink efficacy. Furthermore, an increase in reaction temperature accelerated the reaction without changing the crosslink efficacy. Crosslinking under acidic conditions (pH < 6.0) evoked a reaction between epoxide groups and carboxylic acid groups of collagen. Additional studies showed that no oligomeric crosslinks could be formed. However, hydrolysis of the epoxide groups played a role in the crosslink mechanism especially under acidic reaction conditions. The macroscopic properties of these materials were dependent on the crosslinking method. Whereas a flexible and soft tissue was found if crosslinking was performed at pH < 6.0, a stiff sponge was obtained under alkaline conditions. Reaction of DSC with a monofunctional compound (glycidyl isopropyl ether) led to comparable trends in reaction rate and in similar macroscopical differences in materials as observed with BDDGE. Copyright 1999 John Wiley & Sons, Inc.
机译：真皮绵羊胶原蛋白（DSC）的交联使用1，4-丁二醇二缩水甘油醚（BDDGE）完成。在pH值> 8.0时，BDDGE的环氧基将与胶原的胺基反应。研究了BDDGE浓度，pH，时间和温度的影响。使用4-wt％的BDDGE代替1-wt％导致更快的反应。尽管获得了相似的收缩温度值，但在较低的BDDGE浓度下，较少的伯胺基团反应，这表明交联反应具有较高的功效。 pH从8.5增加到10.5导致反应更快，但交联功效降低。此外，反应温度的升高在不改变交联功效的情况下加速了反应。在酸性条件下（pH <6.0）的交联引发了胶原的环氧基和羧酸基之间的反应。进一步的研究表明，不能形成低聚交联。然而，环氧基的水解特别是在酸性反应条件下在交联机理中起作用。这些材料的宏观性能取决于交联方法。如果在pH <6.0的条件下进行交联，则会发现柔软而柔软的组织，而在碱性条件下会得到坚硬的海绵。 DSC与单官能化合物（缩水甘油基异丙基醚）的反应导致可比的反应速率趋势以及与BDDGE观察到的相似的材料宏观差异。版权所有1999 John Wiley＆Sons，Inc.

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