...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Short-term effects of bisphosphonates on the biomechanical properties of canine bone.
【24h】

Short-term effects of bisphosphonates on the biomechanical properties of canine bone.

机译：双膦酸盐对犬骨生物力学特性的短期影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Periprosthetic osteolysis and aseptic loosening of total joint replacements are believed to be initiated often by abnormal bone resorption induced by prosthetic wear debris. Bisphosphonates can inhibit bone resorption and have been successfully used clinically to treat osteoporosis and Paget's disease. In a recent study it also was shown that a third generation bisphosphonate (alendronate) is effective in preventing wear debris-induced periprosthetic osteolysis. Since inhibition of bone resorption by alendronate may disrupt the delicate balance between bone resorption and formation in normal bone remodeling, it is possible that continuous alendronate therapy may have an adverse effect on the biomechanical properties of bone. Thus the purpose of the present study was to examine the effects of systemic alendronate administration on the biomechanical properties of normal bone using a canine total hip arthroplasty model. We evaluated the biomechanical properties of femora from canines that had received total hip replacements on one side and had been given oral alendronate daily for 23 weeks. The biomechanical properties assessed were fracture toughness, elastic modulus, tensile strength, microhardness, porosity, and weight fractions of the mineral and organic phases of bone. Also, bone microstructure was examined using optical microscopy. Our results indicate that in the short term alendronate therapy does not have any adverse effects on the intrinsic biomechanical properties of canine bone. However, the long-term effects of alendronate therapy still need to be investigated.Copyright 1999 John Wiley & Sons, Inc.
机译：人们普遍认为，假体磨损碎片引起的骨吸收异常，通常会引起假体周围的骨溶解和无菌性松动。双膦酸盐可抑制骨吸收，已在临床上成功用于治疗骨质疏松症和Paget病。在最近的研究中，还显示出第三代双膦酸酯（阿仑膦酸酯）可有效防止磨损碎片引起的假体周围骨质溶解。由于阿仑膦酸盐对骨吸收的抑制作用可能会破坏正常骨重塑中骨吸收与骨形成之间的微妙平衡，因此持续的阿仑膦酸盐治疗可能会对骨骼的生物力学特性产生不利影响。因此，本研究的目的是使用犬类全髋关节置换模型检查全身使用阿仑膦酸盐对正常骨骼的生物力学特性的影响。我们评估了从一侧接受全髋关节置换并每天口服阿仑膦酸钠达23周的犬股骨的生物力学特性。评估的生物力学性能为骨折韧性，弹性模量，拉伸强度，显微硬度，孔隙率以及骨骼的矿物相和有机相的重量分数。另外，使用光学显微镜检查了骨的微观结构。我们的结果表明，短期内阿仑膦酸盐治疗对犬骨的内在生物力学特性没有任何不利影响。但是，阿仑膦酸盐治疗的长期效果仍然有待研究。版权所有1999 John Wiley＆Sons，Inc.

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号