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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Noninvasive bone replacement with a new injectable calcium phosphate biomaterial
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Noninvasive bone replacement with a new injectable calcium phosphate biomaterial

机译：用新型可注射磷酸钙生物材料进行无创骨替代

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The use of injectable calcium phosphate (CaP) biomaterials in noninvasive surgery should provide efficient bone colonization and implantation. Two different kinds of injectable biomaterials are presently under development: ionic hydraulic bone cements that harden in vivo after injection, and an association of biphasic calcium phosphate (BCP) ceramic granules and a water-soluble polymer vehicle (a technique particularly investigated by our group), providing an injectable CaP BONE substitute (IBS). In our study, we compared these two approaches, using physicochemical characterizations and in vivo evaluations in light microscopy, scanning electron microscopy, and three-dimensional microtomography with synchrotron technology. Three week after implantation in rabbit bone, both biomaterials showed perfect biocompatibility and bioactivity, but new bone formation and degradation of the biomaterial were significantly greater for BCP granules than for ionic cement. Newly formed bone developed, binding the BCP granules together, whereas new bone grew only on the surface of the cement, which remained dense, with no obvious degradation 3 weeks after implantation. This study confirms that BCP granules carried by a cellulosic polymer conserve bioactivity and are conducive to earlier and more extensive bone substitution than a carbonated-hydroxyapatite bone cement. The presence of intergranular spaces in the BCP preparation, as shown on microtomography imaging, seems particularly favorable, allowing body fluids to reach each BCP granule immediately after implantation. Thus, the IBS functions as a completely interconnected ceramic with total open macroporosity. This new bone replacement approach should facilitate microinvasive bone surgery and local delivery of bone therapy agents.
机译：在无创手术中使用可注射磷酸钙（CaP）生物材料应能提供有效的骨定植和植入。目前正在开发两种不同类型的可注射生物材料：注射后在体内变硬的离子型水硬性骨水泥，以及双相磷酸钙（BCP）陶瓷颗粒和水溶性聚合物媒介物的结合（我们小组专门研究的一种技术） ，提供可注射的CaP BONE替代品（IBS）。在我们的研究中，我们比较了这两种方法，使用了理化特性和在光学显微镜，扫描电子显微镜和带有同步加速器技术的三维显微断层摄影术中进行的体内评估。植入兔骨三周后，两种生物材料均显示出完美的生物相容性和生物活性，但BCP颗粒的新骨形成和生物材料的降解显着大于离子水泥。形成了新形成的骨头，将BCP颗粒结合在一起，而新骨头仅在水泥表面生长，该表面保持致密，植入后3周无明显降解。这项研究证实，由纤维素聚合物携带的BCP颗粒可保持生物活性，并且比碳酸-羟基磷灰石骨水泥有利于更早更广泛的骨替代。如显微断层扫描成像所示，BCP制剂中存在晶间间隙似乎是特别有利的，允许体液在植入后立即到达每个BCP颗粒。因此，IBS用作具有完全开放大孔的完全互连的陶瓷。这种新的骨替代方法应有助于微创骨手术和骨治疗剂的局部递送。

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